女性骨质疏松症管理的个性化医学方法:整合遗传学、药物基因组学和精确治疗

Seyi Samson Enitan, Esther Ngozi Adejumo, John Osaigbovoh Imaralu, Ayodele Ademola Adelakun, Oluwakemi Anike Ladipo, Comfort Bosede Enitan
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引用次数: 1

摘要

骨质疏松症已成为绝经后妇女的一个重要健康问题。解决这一问题需要多方面的方法,包括遗传学、药物基因组学、骨转换标志物、生活方式因素、并发医疗条件、生物标志物和先进的成像技术。尽管如此,在成本效益和道德考虑方面的挑战确实存在。幸运的是,技术进步和研究努力的融合提供了一条充满希望的轨迹。将基因检测和药物基因组学整合到临床实践中具有巨大的潜力。这种集成使医疗保健专业人员能够预测治疗反应并确定易感性升高的个体,从而能够实施量身定制的有效干预措施,从而优化结果——个性化医疗。鉴于骨质疏松症错综复杂的本质,个性化的治疗策略将极大地有利于与这种疾病搏斗的女性。进一步的研究和合作努力是推动该领域进步的必要条件,为进一步的突破铺平道路。
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Personalized medicine approach to osteoporosis management in women: integrating genetics, pharmacogenomics, and precision treatments
Osteoporosis has emerged as a significant health issue among postmenopausal women. Addressing this concern necessitates a multifaceted approach encompassing genetics, pharmacogenomics, bone turnover markers, lifestyle factors, concurrent medical conditions, biomarkers, and advanced imaging techniques. Nonetheless, challenges in terms of cost-effectiveness and ethical considerations do exist. Fortunately, the convergence of technological progress and research endeavors offers a promising trajectory. The integration of genetic testing and pharmacogenomics into clinical practice holds substantial potential. This integration empowers healthcare professionals to forecast treatment responses and pinpoint individuals with elevated susceptibility, thereby enabling the implementation of tailored and efficacious interventions that optimize outcomes – personalized medicine. Given the intricate nature of osteoporosis, personalized strategies stand to greatly benefit women grappling with this condition. Further research and collaborative efforts are imperative to propel advancements within this domain, paving the way for further breakthroughs.
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