Sneha Kashid, A. Suttee, P. Kadam, Gopal L. Khatik, Ramesh Kasarla
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An In- Silico Studies for Immunomodulatory Potential of Phytoconstituents from a Naturally Occurring Herb Nigella Sativa
are synthetic standards. All the phytoconstituents showed good binding affinities with 1M48 (IL-2) protein in the range of -4.3 to - 7.3 kcal/mol, while on 1P9M (IL-6) protein, the binding affinities observed to be in the range of - 5.2 to -9.8 kcal/mol. The in-silico ADME studies showed that these phytoconstituents have better druggability and no cytotoxicity. The current study showed that the immunomodulatory properties of N. Sativa are from Nigellamine C.
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