目的:估计某地区医院CBNAAT检测的肺结核患者中利福平耐药结核病的点患病率,并采用logistic回归数学模型对数据进行分析

S. Rajamani
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摘要

本研究的目的是估计基于核酸扩增试验(CBNAAT)检测的淋巴结结核分枝杆菌耐利福平点流行率,并采用logistic回归数学模型进行分析。2019年7月至2020年2月,在三级医疗机构的耳鼻喉科进行了一项观察性横断面研究。鉴定出耐利福平分枝杆菌;对数据进行制表和分析,以找出利福平耐药结核的点患病率。共有37名到OPD就诊的患者被纳入研究。通过细针抽吸细胞学(FNAC)或直接活检确认结核。分析患者的人口学特征。建立了该地区利福平耐药的逻辑回归数学模型。使用Jamovi软件计算相关矩阵。在logistic回归模型中,利福平耐药性为因变量。VA、VB水平,后三角组淋巴结最常受累。结果发现,耐利福平分枝杆菌的感染率较高,达89.189% (p<0.01)。与利福平敏感患者相比,利福平耐药患者每期治疗失败的几率(p=0.0291)高2.9672。女性携带利福平耐药分枝杆菌的风险高于男性。
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To estimate the point prevalence of Rifampicin re-sistant tuberculosis in extra pulmonary tuberculosis patients' as detected by CBNAAT in a district hospital and to analyze the data using logistic regression mathematical model
The aim of this study was to estimate the point prevalence of Rifampicin resistant Mycobacteria causing tuberculosis of lymph node as detected by cartridge based nucleic acid amplification test (CBNAAT) and analyzed using logistic regression mathematical modeling. An observational cross-sectional study was carried out in the Department of Otorhinolaryngology from July 2019 to February 2020 in a tertiary healthcare setting. Rifampicin resistant Mycobacteria were identified; data tabulated and analyzed to find the point prevalence of Rifampicin resistant tuberculosis. A total of 37 patients who presented to the OPD were included in the study. Confirmation of the tuberculosis was done either by fine needle aspiration cytology (FNAC) or by direct biopsy. Demographic characteristics of the patients were analyzed. A logical regression mathematical model of Rifampicin resistance in the district was created. Correlation matrix was calculated using Jamovi software. of Rifampicin resistance was dependent variable in logistic regression modeling. Levels VA and VB, posterior triangle group lymph nodes were most commonly involved. It was found that there is high prevalence 89.189% (p<0.01) of Rifampicin resistant Mycobacteria. Rifampicin resistance a 2.9672 greater odds per stage higher chance p=0.0291) treatment failure as compared to Rifampicin sensitive patients. Females have higher risk of harbouring Rifampicin Resistant Mycobacteria than males.
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