脊髓损伤后心血管功能障碍的危险因素及预防。文献综述

IF 0.5 Pharmacophore Pub Date : 2023-01-01 DOI:10.51847/iae3qqag4f
Radu Fodor, Florica Voiță-Mekereș, M. Indrieș, Corina Beiușanu, Gineta Andreescu, Ioan Bogdan Voiță, Hassan Noor, T. Maghiar
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引用次数: 0

摘要

本文旨在分析脊髓损伤(SCI)后可能增加的心血管危险因素。综合考虑脊髓损伤的病理生理机制、临床表现、近期和远期影响,评估心血管疾病的患病率。体力活动减少、低HDL胆固醇、体脂百分比增加、葡萄糖耐量差、胰岛素抵抗、心理社会因素以及脊髓损伤对新出现危险因素的假设影响都是脊髓损伤后潜在的心血管危险因素。营养咨询和干预尤其重要,因为脊髓损伤患者经常吃得比理想的要少。筛查危险因素和在全球范围内评估冠心病风险是预防的第一步。据报道,慢性脊髓损伤患者更容易出现糖耐量差、胰岛素抵抗和高胰岛素血症。这些患者的重要治疗包括体重管理、饮食调整、运动和血糖控制。成功预防以降低心血管疾病的风险需要患者和医生双方的动机。这是一篇在知识共享署名-非商业-相同方式共享4.0许可证下发布的开放获取文章,该许可证允许其他人在作者署名和新创作在相同条款下授权的前提下,对作品进行重新混合、调整和非商业地构建。
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Risk Factors and Prevention of Cardiovascular Dysfunctions After Spinal Cord Injuries. A Literature Review
This paper aims to analyze the potentially increased cardiovascular risk factors after spinal cord injury (SCI). Taking into account the pathophysiological mechanism of SCI, clinical presentation, and short-and long-term effects, this paper evaluates the prevalence of cardiovascular disorders. Reduced physical activity, low HDL cholesterol, an increase in body fat percentage, poor glucose tolerance, insulin resistance, psychosocial factors, and the hypothesised impacts of SCI on emerging risk factors are all potential increased cardiovascular risk factors following SCI. Nutritional counselling and intervention are especially crucial because people with SCI frequently eat less than is ideal. Screening for risk factors and a worldwide assessment of the risk of coronary heart disease are the first steps in prevention. People with chronic SCI are more likely to have poor glucose tolerance, insulin resistance, and hyperinsulinemia, according to reports. Important therapies for these patients include weight management, dietary adjustments, exercise, and glycemic control. Successful prevention to lower the risk of cardiovascular disease requires both patient and physician motivation. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms.
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Pharmacophore
Pharmacophore PHARMACOLOGY & PHARMACY-
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