益生菌在炎症性肠病中的作用

IF 0.4 Q3 MEDICINE, GENERAL & INTERNAL Rawal Medical Journal Pub Date : 2023-01-01 DOI:10.5455/rmj.20230207042401
D. Darmadi, D. Ariestine, Sem S. Surja
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引用次数: 0

摘要

炎症性肠病(IBD)包括溃疡性结肠炎(UC)和克罗恩病(CD)。近年来,IBD的全球发病率呈上升趋势。据推测,西化在这一现象中发挥了作用。炎症是IBD的基本病因。遗传和环境因素是IBD的重要决定因素。胃肠道微生物是环境因素的一个组成部分。平衡状态的微生物环境对维持正常的胃肠功能至关重要。生态失调是胃肠道有益微生物和致病微生物的失衡,可能引起炎症并导致IBD。生态失调导致促炎活性增加,抗炎活性降低,胃肠道黏膜屏障被破坏,炎症延长。益生菌有望在疾病过程中修复生态失调和减轻炎症。在人类的研究报告中,益生菌与UC的标准治疗一起给予了有希望的结果。相比之下,益生菌在乳糜泻中几乎没有积极作用。益生菌作为辅助治疗可能被认为是UC患者的辅助治疗,而不是乳糜泻。
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Role of probiotics in inflammatory bowel disease
Inflammatory bowel disease (IBD) consists of ulcerative colitis (UC) and Crohn’s disease (CD). The global incidence of IBD is increasing recently. Westernization is hypothesized to play role in this phenomenon. Inflammation is the basic etiology of IBD. Genetic and environmental factors are important determinants of IBD. Gastrointestinal microorganism is a component of the environmental factors. Balanced-state microorganism environment is important to maintain normal gastrointestinal function. Dysbiosis, an imbalance in beneficial and pathogenic gastrointestinal microorganism, may elicit inflammation and result in IBD. Dysbiosis causes increased pro-inflammatory activity, decreased anti-inflammatory activity, disrupted gastrointestinal mucosal barrier, and prolonged inflammation. Probiotics are hoped to mend the dysbiosis and alleviate inflammation along with disease course. Studies in human reported that administration of probiotics along with standard therapy for UC gives promising result. In contrast, probiotics have little or no positive effect in CD. Probiotics as adjunctive therapy may be considered in managing patients with UC but not with CD.
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来源期刊
Rawal Medical Journal
Rawal Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
0.70
自引率
0.00%
发文量
6
期刊介绍: RMJ is a general Medicine publication and accepts oorigial articles, editorials, case reports and commentaries. It aims to dessiminate medical knowldge to professional community.
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