基于1-((2-羟基乙氧基)甲基)-5-(苯基硫)- 1h -1,2,4-三唑-3-羧酰胺抗癌核苷的合成及x射线结构

Yu Lei, Dehua Zhang, Yang Liu, Guanghui Tian, Hongguang Ge
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引用次数: 2

摘要

以1,2,4-三唑核苷和1-(2-羟基乙氧基)甲基)-5-(苯基硫代)- 1h -1,2,4-三唑-3-羧基酰胺为基础合成了一对新的抗癌核苷,并以优异的产率得到了相应的产物。单晶x射线衍射证实了其结构和构象。
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Synthesis and X-Ray Structure of New Anticancer Nucleosides Based on 1-((2-Hydroxyethoxy)methyl)-5-(phenylthio)-1H-1,2,4-triazole-3-carboxamide
A pair of new anticancer nucleosides based on 1,2,4-triazole nucleosides and 1-((2-hydroxyethoxy) methyl)-5-(phenylthio)-1H-1,2,4-triazole-3-carboxamide have been synthesized, and have given the corresponding products in excellent yields. Its structures and conformations were confirmed by single crystal X-ray diffraction.
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