{"title":"重要抗癌核苷中间体(2R,3S,4S,5R)-2-(乙酰氧基甲基)-5-(3-溴-5-(甲氧基羰基)- 1h -1,2,4-三唑-1-基)四氢呋喃- 3,4-二乙酸二酯的合成和x射线结构","authors":"Yang Liu, Guanghui Tian, Hongguang Ge, Xiaoyan Cao, Daihua Hu, Dehua Zhang","doi":"10.4236/JCPT.2014.43018","DOIUrl":null,"url":null,"abstract":"An \nimportant anticancer nucleosides intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5-(3-bromo-5-(methoxycar-bonyl)-1H-1,2,4-triazol-1-yl)tetrahydrofuran-3,4-diyl \ndiacetate was synthesized by directly coupling the bromotriazole with the \nprotected ribose sugar, and have given the corresponding product in moderate \nyield. Its structure and conformation were confirmed by single crystal X-ray \ndiffraction.","PeriodicalId":64440,"journal":{"name":"结晶过程及技术期刊(英文)","volume":"04 1","pages":"140-144"},"PeriodicalIF":0.0000,"publicationDate":"2014-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Synthesis and X-Ray Structure of Important Anticancer Nucleosides Intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5- (3-bromo-5-(methoxycarbonyl)- 1H-1,2,4-triazol-1-yl)tetrahydrofuran- 3,4-diyl Diacetate\",\"authors\":\"Yang Liu, Guanghui Tian, Hongguang Ge, Xiaoyan Cao, Daihua Hu, Dehua Zhang\",\"doi\":\"10.4236/JCPT.2014.43018\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"An \\nimportant anticancer nucleosides intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5-(3-bromo-5-(methoxycar-bonyl)-1H-1,2,4-triazol-1-yl)tetrahydrofuran-3,4-diyl \\ndiacetate was synthesized by directly coupling the bromotriazole with the \\nprotected ribose sugar, and have given the corresponding product in moderate \\nyield. Its structure and conformation were confirmed by single crystal X-ray \\ndiffraction.\",\"PeriodicalId\":64440,\"journal\":{\"name\":\"结晶过程及技术期刊(英文)\",\"volume\":\"04 1\",\"pages\":\"140-144\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-06-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"结晶过程及技术期刊(英文)\",\"FirstCategoryId\":\"1087\",\"ListUrlMain\":\"https://doi.org/10.4236/JCPT.2014.43018\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"结晶过程及技术期刊(英文)","FirstCategoryId":"1087","ListUrlMain":"https://doi.org/10.4236/JCPT.2014.43018","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis and X-Ray Structure of Important Anticancer Nucleosides Intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5- (3-bromo-5-(methoxycarbonyl)- 1H-1,2,4-triazol-1-yl)tetrahydrofuran- 3,4-diyl Diacetate
An
important anticancer nucleosides intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5-(3-bromo-5-(methoxycar-bonyl)-1H-1,2,4-triazol-1-yl)tetrahydrofuran-3,4-diyl
diacetate was synthesized by directly coupling the bromotriazole with the
protected ribose sugar, and have given the corresponding product in moderate
yield. Its structure and conformation were confirmed by single crystal X-ray
diffraction.
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