布洛芬晶体热分解反应速率模型

结晶过程及技术期刊(英文) Pub Date : 2014-04-03 DOI:10.4236/JCPT.2014.42010

S. Ramukutty, E. Ramachandran

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引用次数: 32

摘要

采用非等温分析方法研究了外消旋布洛芬晶体的分解动力学。热重分析表明，布洛芬在152.6℃时热稳定，初始质量损失仅由蒸发引起。采用Coats-Redfern (CR)积分法测定了布洛芬分解的活化能、指前因子、活化熵和吉布斯自由能。几何收缩模型被发现是最适合的。布洛芬热分解的Arrheinus方程为k = (1.1 × 107) e-79125 /RT sec-1。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Reaction Rate Models for the Thermal Decomposition of Ibuprofen Crystals

Kinetics of the decomposition of racemic ibuprofen crystals were studied by non-isothermal analysis. Thermogravimetric analysis revealed that ibuprofen is thermally stable up to 152.6°C and the initial loss of mass was due to evaporation only. Activation energy, pre-exponential factor, activation entropy and Gibbs free energy for the decomposition of ibuprofen were determined using the integral method of Coats-Redfern (CR). Geometrical contraction models were found to be the best fits. The Arrheinus equation for the thermal decomposition of ibuprofen is k = (1.1 × 107) e–79125/RT sec–1.

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结晶过程及技术期刊(英文)

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