阿尔茨海默病的计算模型

Scholarpedia journal Pub Date : 2017-01-01 DOI:10.4249/scholarpedia.32144

Vassilis Cutsuridis, A. Moustafa

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引用次数: 13

摘要

已经有一些设计AD计算模型的尝试。其中一些模型关注海马体功能，但许多模型在模拟淀粉样斑块和神经原纤维缠结的确切效果方面存在问题。参见Duch(2007)对一些AD模型的回顾。下面，我们将讨论AD的生化、单细胞、生物物理尖峰以及系统级和抽象模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Computational models of Alzheimer's disease

There have been a few attempts to design computational models of AD. Some of these models focus on hippocampus function yet many suffer from simulating exact effects of amyloid plaques and neurofibrillary tangles. See Duch (2007) for a review of some AD models. Below, we discuss biochemical, single cell, biophysical spiking, and systems-level and abstract models of AD.

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