Gülter Devrim Akyol, Mukadder Inci Baser Kolcu, Nazlı Zeynep Alpaslan, Filiz Taşpınar, R. Mızrak, S. Tunç, Bülend İnanç
{"title":"一种创新型生物因子MTA产品在不同人类细胞中的细胞毒性研究:一项初步研究","authors":"Gülter Devrim Akyol, Mukadder Inci Baser Kolcu, Nazlı Zeynep Alpaslan, Filiz Taşpınar, R. Mızrak, S. Tunç, Bülend İnanç","doi":"10.5114/jos.2023.128770","DOIUrl":null,"url":null,"abstract":"Objectives: The aim of this study was to investigate the cyto-toxicity of Biodentine, Angelus MTA, BIOfactor MTA on 3T3L-1 fibroblast, and Saos-2 osteosarcoma cell lines with different dilution of all products. Material and methods: 3T3-1 fibroblast was applied to stimulate pulp cells in cell viability test. In order to gene rate an osteoblastic cell-like model, only Saos-2 cells were used. MTT test was utilized to measure cell cytotoxicity in different dilution of all MTA products. SPSS package program was applied to perform Kruskal-Wallis, one-way ANOVA and two-way ANOVA tests. Results: According to results, while Biodentine, Angelus MTA and BIOfactor MTA showed cyto-toxic effects in 1 : 1 and 1 : 2 dilutions, they were not cyto-toxic in 1 : 4 and 1 : 8 dilutions. Conclusions: MTA products have similar cyto-toxicity. BIOfactor MTA has a cyto-toxic effect as other similar products.","PeriodicalId":35469,"journal":{"name":"Journal of Stomatology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Investigation of cyto-toxicity of an innovative BIOfactor MTA product in different human cells: a pilot study\",\"authors\":\"Gülter Devrim Akyol, Mukadder Inci Baser Kolcu, Nazlı Zeynep Alpaslan, Filiz Taşpınar, R. Mızrak, S. Tunç, Bülend İnanç\",\"doi\":\"10.5114/jos.2023.128770\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objectives: The aim of this study was to investigate the cyto-toxicity of Biodentine, Angelus MTA, BIOfactor MTA on 3T3L-1 fibroblast, and Saos-2 osteosarcoma cell lines with different dilution of all products. Material and methods: 3T3-1 fibroblast was applied to stimulate pulp cells in cell viability test. In order to gene rate an osteoblastic cell-like model, only Saos-2 cells were used. MTT test was utilized to measure cell cytotoxicity in different dilution of all MTA products. SPSS package program was applied to perform Kruskal-Wallis, one-way ANOVA and two-way ANOVA tests. Results: According to results, while Biodentine, Angelus MTA and BIOfactor MTA showed cyto-toxic effects in 1 : 1 and 1 : 2 dilutions, they were not cyto-toxic in 1 : 4 and 1 : 8 dilutions. Conclusions: MTA products have similar cyto-toxicity. BIOfactor MTA has a cyto-toxic effect as other similar products.\",\"PeriodicalId\":35469,\"journal\":{\"name\":\"Journal of Stomatology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Stomatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5114/jos.2023.128770\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Dentistry\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Stomatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5114/jos.2023.128770","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Dentistry","Score":null,"Total":0}
Investigation of cyto-toxicity of an innovative BIOfactor MTA product in different human cells: a pilot study
Objectives: The aim of this study was to investigate the cyto-toxicity of Biodentine, Angelus MTA, BIOfactor MTA on 3T3L-1 fibroblast, and Saos-2 osteosarcoma cell lines with different dilution of all products. Material and methods: 3T3-1 fibroblast was applied to stimulate pulp cells in cell viability test. In order to gene rate an osteoblastic cell-like model, only Saos-2 cells were used. MTT test was utilized to measure cell cytotoxicity in different dilution of all MTA products. SPSS package program was applied to perform Kruskal-Wallis, one-way ANOVA and two-way ANOVA tests. Results: According to results, while Biodentine, Angelus MTA and BIOfactor MTA showed cyto-toxic effects in 1 : 1 and 1 : 2 dilutions, they were not cyto-toxic in 1 : 4 and 1 : 8 dilutions. Conclusions: MTA products have similar cyto-toxicity. BIOfactor MTA has a cyto-toxic effect as other similar products.
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