Сationic介芳基卟啉及其Zn(II)配合物对金黄色葡萄球菌的光失活作用

IF 1 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY Macroheterocycles Pub Date : 2021-01-01 DOI:10.6060/mhc210130z

I. O. Savelyeva, Yulia S. Bortnevskaya, A. Y. Usanev, N. A. Bragina, A. Mironov, A. Ignatova, A. Feofanov, K. A. Zhdanova

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引用次数: 3

摘要

本文合成了阳离子介芳基取代卟啉及其Zn(II)配合物。用多核核磁共振谱、电子能谱和esi质谱对化合物进行了表征。研究了卟啉的光动力学活性与金黄色葡萄球菌及其生物膜的关系。Pluronic F-127聚合物胶束作为纳米运载工具的应用支持合成的卟啉具有高的抗菌光动力活性。揭示了中心金属原子对合成化合物的暗毒性和光毒性的影响。未辐照的控制板。统计数据。结果被认为具有统计学意义，置信度为95%。所有实验至少重复3次，结果具有可比性。采用学生系数进行统计分析。结果以mean±SD表示。

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Photoinactivation of S. Aureus by Сationic meso-Arylporphyrin and Its Zn(II) Complex

In this work, cationic meso-arylsubstituted porphyrin and its Zn(II) complex were synthesized. The compounds were characterized by multinuclear NMR spectroscopy, electronic spectroscopy and ESI-mass spectrometry. The photodynamic activity of the porphyrins was studied in relation to S. aureus bacteria and their biofilms. Application of polymeric micelles of Pluronic F-127 as nanosized delivery vehicles supports high antimicrobial photodynamic activity of the synthesized porphyrins. The influence of the central metal atom on the dark and light-induced toxicity of the synthesized compounds was revealed. non-irradiated control plate. Statistics . The results were considered statistically signifi cant with a 95 % confidence level. All experiments were repeated at least 3 times with comparable results. Statistical analysis was performed using the Student’s coefficient. Results are presented as mean ± SD.

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来源期刊

Macroheterocycles CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

2.30

自引率

21.40%

发文量

期刊介绍： The journal is a forum for the specialists investigating macroheterocyclic compounds. It publishes original experimental and theoretical works (full papers and short communications) and reviews on synthesis, structural characterization, physical and coordination chemistry as well as practical application of macroheterocycles.