冠状动脉支架植入有严重感染甚至死亡的终身风险

Shohei Mitta, Ryutaro Kimata, H. Ogura, Etsuji Umeda, N. Ishida, K. Shimabukuro, K. Doi
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摘要

住院的第二天,她抱怨说话困难。她接受了脑磁共振成像(MRI),再次发生冠状动脉支架感染极为罕见且难以识别。确诊延误往往导致死亡。我们描述了一例支架植入后8年发生的感染。一名66岁妇女因高热入院。她在59岁时接受了右冠状动脉裸金属支架的植入。她还在58岁时接受了肾移植,并一直服用多种免疫抑制剂。虽然入院时全身计算机断层扫描(CT)未发现细菌感染源,但血液培养培养出金黄色葡萄球菌。脑磁共振成像显示多发性脑梗死。怀疑感染性心内膜炎(IE),但经胸和经食管超声心动图未发现IE的证据。患者经静脉注射抗生素及免疫球蛋白后发热,血培养阴性。然而,超声心动图显示左心室功能下降,此后,患者发生急性下壁心肌梗死。紧急冠状动脉造影显示右冠状动脉起源处有一个大的冠状动脉瘤,之前的冠状动脉支架植入处,重复CT也证实了一个非常迅速发展的冠状动脉瘤。我们紧急切除了霉菌性动脉瘤和受感染的支架。然而,手术前右心脏已经严重受损。她接受了4天的静脉-动脉体外膜氧合,但出现细菌性肺炎并于术后第15天死亡。这个病例强调了冠状动脉支架植入几年后感染的长期风险。
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Coronary Stent Implantation Poses Lifelong Risk of Severe Infection or Even Death
On hospital day 2, she complained of difficulty in speaking. She underwent brain magnetic resonance imaging (MRI) that re-Case Coronary stent infection is extremely rare and difficult to identify. Delay in definite diagnosis often leads to death. We describe a case of stent infection that occurred 8 years after implantation. A 66-year-old woman was admitted to our hospital with high-grade fever. She underwent placement of a bare-metal stent to the right coronary artery at 59 years of age. She also underwent kidney transplantation at 58 years of age and had been taking multiple immunosuppressants. Although whole-body computed tomography (CT) scan at the time of admission found no source of bacterial infection, blood cultures grew Staphylococcus aureus . Brain magnetic resonance imaging revealed multiple cerebral infarctions. Infective endocarditis (IE) was suspected but transthoracic and transesophageal echocardiogram found no evidence of IE. The patient became afebrile after administration of intravenous antibiotics and intravenous immunoglobulin, and blood cultures were negative. However, echocardiogram revealed a decline in left ventricle function, and thereafter, the patient developed acute inferior wall myocardial infarction. Urgent coronary angiography exhibited a large coronary artery aneurysm at the origin of the right coronary artery where a previous coronary stent was implanted, and repeat CT also confirmed a very rapidly developing coronary aneurysm. We performed emergent removal of the mycotic aneurysm along with the infected stent. However, the right heart had been severely damaged prior to surgery. She underwent four days of veno-arterial extracorporeal membrane oxygenation but developed bacterial pneumonia and expired on postoperative day 15. This case highlights the long-term risk of coronary stent infection several years after implantation.
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