摩擦学试验的当前作用:争取医药和化妆品的充分表征

Q4 Pharmacology, Toxicology and Pharmaceutics Arhiv za Farmaciju Pub Date : 2023-01-01 DOI:10.5937/arhfarm73-43515
Anđela Tošić, Tijana Stankovic, T. Ilić, S. Savić, I. Pantelić
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引用次数: 0

摘要

摩擦学通过评估摩擦、润滑和/或磨损,研究直接或间接接触的两种物质/物体表面发生的事件。特别是,摩擦测量可以提供有关(每)口服药物制剂的质地特征的信息,有助于了解适口性。另一方面,摩擦学测试已被更广泛地用于表征局部制剂(药物,化妆品),从而深入了解这些制剂的触觉和质地特性。然而,这些测试通常与流变学、结构和某些生物物理方法相结合。此外,用于构建人工关节和关节软骨的材料是真正的摩擦学系统,开发和优化的目的是为了具有与天然材料相似的性能。由于摩擦学研究通常可用于评估范围广泛的药物剂型和产品,因此所使用的设备可能相当多样化。因此,这项工作的一个特殊部分致力于描述测试设备的规格和应用协议。对最近发现的监管现象的调查,如局部制剂的载体/基础的转化/变态,使摩擦学作为一种潜在的评估方法重新受到关注。
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Current role of tribological tests: Striving for full characterization of medicinal and cosmetic products
Tribology investigates the events that happen on the surfaces of two substances/objects that are in direct or indirect contact through assessing friction, lubrication and/or wear. In particular, friction measurements could provide the information on the textural characteristics of (per)oral pharmaceutical preparations and contribute to the understanding of palatability. On the other hand, tribological tests have been more intensively used to characterize topical preparations (pharmaceutical, cosmetic), giving a thorough insight into the tactile and texture properties of these preparations. However, these tests are often combined with rheological, textural, and certain biophysical approaches. Additionally, the materials used for constructing artificial joints and articular cartilages are true tribological systems, developed and optimized in order to have properties that resemble the natural ones. Since tribological studies can be used to assess a wide range of drug dosage forms and products in general, the equipment used may be quite diverse. Accordingly, a special section of this work is committed to the description of the testing equipment's specifications and the applied protocols. The investigation of recently regulatory discovered phenomena, such as transformation/metamorphosis of the vehicle/base of topical preparations, have brought tribology back into focus as a potential assessment method.
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来源期刊
Arhiv za Farmaciju
Arhiv za Farmaciju Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
自引率
0.00%
发文量
19
审稿时长
12 weeks
期刊最新文献
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