左乙拉西坦的即时超敏反应：一例病例报告研究。

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY DARU Journal of Pharmaceutical Sciences Pub Date : 2024-06-01 Epub Date: 2023-11-02 DOI:10.1007/s40199-023-00488-6

Mahnaz Sadat Hosseini, Soha Namazi

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摘要

背景：抗惊厥药物是引起迟发性超敏反应的最常见原因之一，如嗜酸性粒细胞增多症和全身症状药物反应（DRESS）、Stevens-Johnson综合征（SJS）和中毒性表皮坏死松解症（TEN）。这些反应在苯妥英和卡马西平等芳香类抗惊厥药物中更为普遍。然而，急性超敏反应，如荨麻疹、血管性水肿和抗惊厥药物过敏反应是罕见的。我们描述了一位51岁的女性，她在静脉注射左乙拉西坦24小时后，手腕上出现了扩散性皮疹，伴有荨麻疹和瘙痒。结论：临床医生应注意静脉注射左乙拉西坦的即时超敏反应。

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Immediate hypersensitivity reaction to levetiracetam: a case report study.

Background: Anticonvulsant drugs are one of the most common causes of delayed hypersensitivity reactions, such as drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). These reactions are more prevalent with aromatic anticonvulsant drugs such as phenytoin and carbamazepine. However, immediate hypersensitivity reactions such as urticaria, angioedema, and anaphylaxis with anticonvulsant drugs are rare. We describe a 51-year-old woman who developed spreading skin rashes on her wrists with urticaria and pruritus 24 h after receiving intravenous levetiracetam.

Conclusion: Clinicians should be aware of immediate hypersensitivity reactions with intravenous levetiracetam.

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DARU Journal of Pharmaceutical Sciences PHARMACOLOGY & PHARMACY-

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期刊介绍： DARU Journal of Pharmaceutical Sciences is a peer-reviewed journal published on behalf of Tehran University of Medical Sciences. The journal encompasses all fields of the pharmaceutical sciences and presents timely research on all areas of drug conception, design, manufacture, classification and assessment. The term DARU is derived from the Persian name meaning drug or medicine. This journal is a unique platform to improve the knowledge of researchers and scientists by publishing novel articles including basic and clinical investigations from members of the global scientific community in the forms of original articles, systematic or narrative reviews, meta-analyses, letters, and short communications.