Arnau Peñalver-Piñol, Yolanda Benavente, Jon Frias-Gomez, Juan Alguacil, Miguel Santibañez, Manuel Contreras-Llanes, Paula Peremiquel-Trillas, Marta López-Querol, Sonia Paytubi, Beatriz Pelegrina, Irene Onieva, José Manuel Martínez, Sergi Fernandez-Gonzalez, Javier de Francisco, Víctor Caño, Joan Brunet, Marta Pineda, Jordi Ponce, Xavier Matias-Guiu, Francesc Xavier Bosch, Silvia de Sanjosé, Laia Alemany, Laura Costas
{"title":"农药职业暴露与子宫内膜癌症筛查病例对照研究。","authors":"Arnau Peñalver-Piñol, Yolanda Benavente, Jon Frias-Gomez, Juan Alguacil, Miguel Santibañez, Manuel Contreras-Llanes, Paula Peremiquel-Trillas, Marta López-Querol, Sonia Paytubi, Beatriz Pelegrina, Irene Onieva, José Manuel Martínez, Sergi Fernandez-Gonzalez, Javier de Francisco, Víctor Caño, Joan Brunet, Marta Pineda, Jordi Ponce, Xavier Matias-Guiu, Francesc Xavier Bosch, Silvia de Sanjosé, Laia Alemany, Laura Costas","doi":"10.1186/s12940-023-01028-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Endometrial cancer is the most common gynaecological tumour in developed countries and disease burden is expected to increase over the years. Identifying modifiable risk factors may help developing strategies to reduce the expected increasing incidence of these neoplasms.</p><p><strong>Objective: </strong>This study evaluates the association between occupational exposure to pesticides and endometrial cancer using data from a recent case-control study in Spain.</p><p><strong>Methods: </strong>The analyses included data from 174 consecutive incident endometrial cancer cases and 216 hospital controls frequency-matched by age. Data were collected through structured epidemiological questionnaires and exposure to pesticides was assessed using a Spanish job-exposure matrix (MatEmESp).</p><p><strong>Results: </strong>Overall, 12% of controls and 18% of cases were occupationally exposed to pesticides. We observed a positive association between occupational exposure to pesticides and endometrial cancer (OR = 2.08; 95% CI = 1.13-3.88 compared to non-exposed). In general, exposures that occurred farther in the past were significantly associated with endometrial cancer. Exposure to insecticides, fungicides and herbicides were positively associated with endometrial cancer (OR = 2.08; 95% CI = 1.13-3.88, OR = 4.40; 95% CI = 1.65-13.33, and OR = 5.25; 95% CI = 1.84-17.67, respectively). The agricultural, poultry and livestock activities scenario was associated with endometrial cancer (OR = 4.16; 95% CI = 1.59-12.32), while the cleaning exposure scenario was not (OR = 1.22; 95% CI = 0.55-2.67).</p><p><strong>Conclusions: </strong>Assessment of occupational exposure to pesticides assessed using a Spanish job-exposure matrix revealed a positive association with endometrial cancer. The elucidation of the role of pesticide compounds on endometrial cancer should shed a light on the aetiology of this tumour.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":null,"pages":null},"PeriodicalIF":5.3000,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621144/pdf/","citationCount":"0","resultStr":"{\"title\":\"Occupational exposure to pesticides and endometrial cancer in the Screenwide case-control study.\",\"authors\":\"Arnau Peñalver-Piñol, Yolanda Benavente, Jon Frias-Gomez, Juan Alguacil, Miguel Santibañez, Manuel Contreras-Llanes, Paula Peremiquel-Trillas, Marta López-Querol, Sonia Paytubi, Beatriz Pelegrina, Irene Onieva, José Manuel Martínez, Sergi Fernandez-Gonzalez, Javier de Francisco, Víctor Caño, Joan Brunet, Marta Pineda, Jordi Ponce, Xavier Matias-Guiu, Francesc Xavier Bosch, Silvia de Sanjosé, Laia Alemany, Laura Costas\",\"doi\":\"10.1186/s12940-023-01028-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Endometrial cancer is the most common gynaecological tumour in developed countries and disease burden is expected to increase over the years. Identifying modifiable risk factors may help developing strategies to reduce the expected increasing incidence of these neoplasms.</p><p><strong>Objective: </strong>This study evaluates the association between occupational exposure to pesticides and endometrial cancer using data from a recent case-control study in Spain.</p><p><strong>Methods: </strong>The analyses included data from 174 consecutive incident endometrial cancer cases and 216 hospital controls frequency-matched by age. Data were collected through structured epidemiological questionnaires and exposure to pesticides was assessed using a Spanish job-exposure matrix (MatEmESp).</p><p><strong>Results: </strong>Overall, 12% of controls and 18% of cases were occupationally exposed to pesticides. We observed a positive association between occupational exposure to pesticides and endometrial cancer (OR = 2.08; 95% CI = 1.13-3.88 compared to non-exposed). In general, exposures that occurred farther in the past were significantly associated with endometrial cancer. Exposure to insecticides, fungicides and herbicides were positively associated with endometrial cancer (OR = 2.08; 95% CI = 1.13-3.88, OR = 4.40; 95% CI = 1.65-13.33, and OR = 5.25; 95% CI = 1.84-17.67, respectively). The agricultural, poultry and livestock activities scenario was associated with endometrial cancer (OR = 4.16; 95% CI = 1.59-12.32), while the cleaning exposure scenario was not (OR = 1.22; 95% CI = 0.55-2.67).</p><p><strong>Conclusions: </strong>Assessment of occupational exposure to pesticides assessed using a Spanish job-exposure matrix revealed a positive association with endometrial cancer. The elucidation of the role of pesticide compounds on endometrial cancer should shed a light on the aetiology of this tumour.</p>\",\"PeriodicalId\":11686,\"journal\":{\"name\":\"Environmental Health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2023-11-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621144/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Environmental Health\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://doi.org/10.1186/s12940-023-01028-0\",\"RegionNum\":2,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Health","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1186/s12940-023-01028-0","RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
Occupational exposure to pesticides and endometrial cancer in the Screenwide case-control study.
Background: Endometrial cancer is the most common gynaecological tumour in developed countries and disease burden is expected to increase over the years. Identifying modifiable risk factors may help developing strategies to reduce the expected increasing incidence of these neoplasms.
Objective: This study evaluates the association between occupational exposure to pesticides and endometrial cancer using data from a recent case-control study in Spain.
Methods: The analyses included data from 174 consecutive incident endometrial cancer cases and 216 hospital controls frequency-matched by age. Data were collected through structured epidemiological questionnaires and exposure to pesticides was assessed using a Spanish job-exposure matrix (MatEmESp).
Results: Overall, 12% of controls and 18% of cases were occupationally exposed to pesticides. We observed a positive association between occupational exposure to pesticides and endometrial cancer (OR = 2.08; 95% CI = 1.13-3.88 compared to non-exposed). In general, exposures that occurred farther in the past were significantly associated with endometrial cancer. Exposure to insecticides, fungicides and herbicides were positively associated with endometrial cancer (OR = 2.08; 95% CI = 1.13-3.88, OR = 4.40; 95% CI = 1.65-13.33, and OR = 5.25; 95% CI = 1.84-17.67, respectively). The agricultural, poultry and livestock activities scenario was associated with endometrial cancer (OR = 4.16; 95% CI = 1.59-12.32), while the cleaning exposure scenario was not (OR = 1.22; 95% CI = 0.55-2.67).
Conclusions: Assessment of occupational exposure to pesticides assessed using a Spanish job-exposure matrix revealed a positive association with endometrial cancer. The elucidation of the role of pesticide compounds on endometrial cancer should shed a light on the aetiology of this tumour.
期刊介绍:
Environmental Health publishes manuscripts on all aspects of environmental and occupational medicine and related studies in toxicology and epidemiology.
Environmental Health is aimed at scientists and practitioners in all areas of environmental science where human health and well-being are involved, either directly or indirectly. Environmental Health is a public health journal serving the public health community and scientists working on matters of public health interest and importance pertaining to the environment.