麻风患者的Th17细胞和细胞因子：了解免疫反应和极化。

IF 1.8 4区医学 Q2 PARASITOLOGY Revista da Sociedade Brasileira de Medicina Tropical Pub Date : 2023-10-30 eCollection Date: 2023-01-01 DOI:10.1590/0037-8682-0265-2023

Larissa Marchi Zaniolo, Amílcar Sabino Damazo

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引用次数: 0

摘要

尽管与健康对照组相比，麻风病患者血清中的白细胞介素（IL）-17水平存在相互矛盾的数据，但在麻风病的结核样临床形式和1型反应中，更高的水平更为明显。本综述旨在强调Th17细胞及其细胞因子在麻风病中的作用。细胞因子如IL-1β和IL-23诱导Th17，而转化生长因子β和IL-10抑制Th17，表明Th17和调节性T细胞之间的平衡对麻风病的极化至关重要。然而，需要更全面的配对研究来更好地阐明Th17细胞在麻风病中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Th17 Cells and Cytokines in Leprosy: Understanding the Immune Response and Polarization.

While there are conflicting data concerning interleukin (IL)-17 levels in the serum of patients with leprosy compared with those in healthy controls, higher levels have been more evident in the tuberculoid clinical form of leprosy and type 1 reactions. This review aimed to highlight the role of Th17 cells and their cytokines in leprosy. Cytokines such as IL-1β and IL-23 induce Th17, while transforming growth factor beta and IL-10 inhibit Th17, indicating that the balance between Th17 and regulatory T cells is crucial for leprosy polarization. However, more comprehensive paired studies are required to better elucidate the role of Th17 cells in leprosy.

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来源期刊

Revista da Sociedade Brasileira de Medicina Tropical 医学-热带医学

CiteScore

3.40

自引率

10.00%

发文量

195

审稿时长

3-8 weeks

期刊介绍： The Journal of the Brazilian Society of Tropical Medicine (JBSTM) isan official journal of the Brazilian Society of Tropical Medicine) with open access. It is amultidisciplinary journal that publishes original researches related totropical diseases, preventive medicine, public health, infectious diseasesand related matters. Preference for publication will be given to articlesreporting original observations or researches. The journal has a peer-reviewsystem for articles acceptance and its periodicity is bimonthly. The Journalof the Brazilian Society of Tropical Medicine is published in English.The journal invites to publication Major Articles, Editorials, Reviewand Mini-Review Articles, Short Communications, Case Reports, TechnicalReports, Images in Infectious Diseases, Letters, Supplements and Obituaries.