{"title":"更年期肌肉骨骼疾病的功能成像。","authors":"Luca Filippi MD , Riccardo Camedda MD , Viviana Frantellizzi MD, PhD , Nicoletta Urbano MD , Giuseppe De Vincentis MD , Orazio Schillaci MD","doi":"10.1053/j.semnuclmed.2023.10.001","DOIUrl":null,"url":null,"abstract":"<div><p><span><span><span>Menopause-related musculoskeletal (MSK) disorders include osteoporosis, </span>osteoarthritis (OA), </span>sarcopenia<span> and sarco-obesity. This review focuses on the applications of nuclear medicine<span> for the functional imaging of the aforementioned clinical conditions. Bone Scan (BS) with </span></span></span><sup>99m</sup><span><span>Tc-labeled phosphonates, alone or in combination with MRI, can identify “fresh” vertebral collapse due to age-associated osteoporosis and provides quantitative parameters characterized by a good correlation with radiological indices </span>in patients with OA. </span><sup>18</sup><span><span>F-NaF PET<span><span>, particularly when performed by dynamic scan, has given encouraging results for measuring bone turnover in osteoporosis and allows the evaluation of subchondral bone metabolic activity in OA. </span>FDG<span><span> PET can help discriminate between pathological and nonpathological vertebral fractures, especially by applying appropriate SUV-based thresholds. In OA, it can effectively image inflamed joints and support appropriate clinical management. Preliminary evidences suggest a possible application of FDG in sarco-obesity for the detection and quantification of visceral </span>adipose tissue<span> (VAT). Further studies are needed to better define the role of nuclear medicine in menopause-related MSK disease, especially as regards the possible impact of new radiopharmaceuticals (ie, </span></span></span></span>FAPI and RGD peptides) and recent technological advances (eg, total-body PET/CT scanners).</span></p></div>","PeriodicalId":21643,"journal":{"name":"Seminars in nuclear medicine","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Functional Imaging in Musculoskeletal Disorders in Menopause\",\"authors\":\"Luca Filippi MD , Riccardo Camedda MD , Viviana Frantellizzi MD, PhD , Nicoletta Urbano MD , Giuseppe De Vincentis MD , Orazio Schillaci MD\",\"doi\":\"10.1053/j.semnuclmed.2023.10.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span><span>Menopause-related musculoskeletal (MSK) disorders include osteoporosis, </span>osteoarthritis (OA), </span>sarcopenia<span> and sarco-obesity. This review focuses on the applications of nuclear medicine<span> for the functional imaging of the aforementioned clinical conditions. Bone Scan (BS) with </span></span></span><sup>99m</sup><span><span>Tc-labeled phosphonates, alone or in combination with MRI, can identify “fresh” vertebral collapse due to age-associated osteoporosis and provides quantitative parameters characterized by a good correlation with radiological indices </span>in patients with OA. </span><sup>18</sup><span><span>F-NaF PET<span><span>, particularly when performed by dynamic scan, has given encouraging results for measuring bone turnover in osteoporosis and allows the evaluation of subchondral bone metabolic activity in OA. </span>FDG<span><span> PET can help discriminate between pathological and nonpathological vertebral fractures, especially by applying appropriate SUV-based thresholds. In OA, it can effectively image inflamed joints and support appropriate clinical management. Preliminary evidences suggest a possible application of FDG in sarco-obesity for the detection and quantification of visceral </span>adipose tissue<span> (VAT). Further studies are needed to better define the role of nuclear medicine in menopause-related MSK disease, especially as regards the possible impact of new radiopharmaceuticals (ie, </span></span></span></span>FAPI and RGD peptides) and recent technological advances (eg, total-body PET/CT scanners).</span></p></div>\",\"PeriodicalId\":21643,\"journal\":{\"name\":\"Seminars in nuclear medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Seminars in nuclear medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0001299823000818\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in nuclear medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0001299823000818","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Functional Imaging in Musculoskeletal Disorders in Menopause
Menopause-related musculoskeletal (MSK) disorders include osteoporosis, osteoarthritis (OA), sarcopenia and sarco-obesity. This review focuses on the applications of nuclear medicine for the functional imaging of the aforementioned clinical conditions. Bone Scan (BS) with 99mTc-labeled phosphonates, alone or in combination with MRI, can identify “fresh” vertebral collapse due to age-associated osteoporosis and provides quantitative parameters characterized by a good correlation with radiological indices in patients with OA. 18F-NaF PET, particularly when performed by dynamic scan, has given encouraging results for measuring bone turnover in osteoporosis and allows the evaluation of subchondral bone metabolic activity in OA. FDG PET can help discriminate between pathological and nonpathological vertebral fractures, especially by applying appropriate SUV-based thresholds. In OA, it can effectively image inflamed joints and support appropriate clinical management. Preliminary evidences suggest a possible application of FDG in sarco-obesity for the detection and quantification of visceral adipose tissue (VAT). Further studies are needed to better define the role of nuclear medicine in menopause-related MSK disease, especially as regards the possible impact of new radiopharmaceuticals (ie, FAPI and RGD peptides) and recent technological advances (eg, total-body PET/CT scanners).
期刊介绍:
Seminars in Nuclear Medicine is the leading review journal in nuclear medicine. Each issue brings you expert reviews and commentary on a single topic as selected by the Editors. The journal contains extensive coverage of the field of nuclear medicine, including PET, SPECT, and other molecular imaging studies, and related imaging studies. Full-color illustrations are used throughout to highlight important findings. Seminars is included in PubMed/Medline, Thomson/ISI, and other major scientific indexes.