更年期肌肉骨骼疾病的功能成像。

IF 4.6 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Seminars in nuclear medicine Pub Date : 2024-03-01 DOI:10.1053/j.semnuclmed.2023.10.001
Luca Filippi MD , Riccardo Camedda MD , Viviana Frantellizzi MD, PhD , Nicoletta Urbano MD , Giuseppe De Vincentis MD , Orazio Schillaci MD
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引用次数: 0

摘要

更年期相关的肌肉骨骼(MSK)疾病包括骨质疏松症、骨关节炎(OA)、肌肉减少症和肌肉肥胖。这篇综述的重点是核医学在上述临床条件的功能成像中的应用。99mTc标记的膦酸盐骨扫描(BS),单独或与MRI联合使用,可以识别由于年龄相关的骨质疏松症引起的“新鲜”椎骨塌陷,并提供定量参数,其特征是与OA患者的放射学指标具有良好的相关性。18F-NaF-PET,特别是当通过动态扫描进行时,在测量骨质疏松症的骨转换方面给出了令人鼓舞的结果,并允许评估OA的软骨下骨代谢活性。FDG PET可以帮助区分病理性和非病理性脊椎骨折,特别是通过应用适当的基于SUV的阈值。在OA中,它可以有效地对发炎的关节进行成像,并支持适当的临床管理。初步证据表明,FDG在肌肉性肥胖中可能用于内脏脂肪组织(VAT)的检测和定量。需要进一步的研究来更好地确定核医学在更年期相关MSK疾病中的作用,特别是关于新的放射性药物(即FAPI和RGD肽)和最新技术进步(如全身PET/CT扫描仪)的可能影响。
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Functional Imaging in Musculoskeletal Disorders in Menopause

Menopause-related musculoskeletal (MSK) disorders include osteoporosis, osteoarthritis (OA), sarcopenia and sarco-obesity. This review focuses on the applications of nuclear medicine for the functional imaging of the aforementioned clinical conditions. Bone Scan (BS) with 99mTc-labeled phosphonates, alone or in combination with MRI, can identify “fresh” vertebral collapse due to age-associated osteoporosis and provides quantitative parameters characterized by a good correlation with radiological indices in patients with OA. 18F-NaF PET, particularly when performed by dynamic scan, has given encouraging results for measuring bone turnover in osteoporosis and allows the evaluation of subchondral bone metabolic activity in OA. FDG PET can help discriminate between pathological and nonpathological vertebral fractures, especially by applying appropriate SUV-based thresholds. In OA, it can effectively image inflamed joints and support appropriate clinical management. Preliminary evidences suggest a possible application of FDG in sarco-obesity for the detection and quantification of visceral adipose tissue (VAT). Further studies are needed to better define the role of nuclear medicine in menopause-related MSK disease, especially as regards the possible impact of new radiopharmaceuticals (ie, FAPI and RGD peptides) and recent technological advances (eg, total-body PET/CT scanners).

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来源期刊
Seminars in nuclear medicine
Seminars in nuclear medicine 医学-核医学
CiteScore
9.80
自引率
6.10%
发文量
86
审稿时长
14 days
期刊介绍: Seminars in Nuclear Medicine is the leading review journal in nuclear medicine. Each issue brings you expert reviews and commentary on a single topic as selected by the Editors. The journal contains extensive coverage of the field of nuclear medicine, including PET, SPECT, and other molecular imaging studies, and related imaging studies. Full-color illustrations are used throughout to highlight important findings. Seminars is included in PubMed/Medline, Thomson/ISI, and other major scientific indexes.
期刊最新文献
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