骨密度扫描在监测骨质疏松症患者治疗反应中的应用:一项回顾性队列研究。

IF 2.3 Q2 RHEUMATOLOGY International Journal of Rheumatology Pub Date : 2023-10-23 eCollection Date: 2023-01-01 DOI:10.1155/2023/2160346
Mohammed O Ibrahim, Ahmad Kolleri, Amel Ginawi
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引用次数: 0

摘要

骨质疏松症是一种代谢性骨病,其特征是骨密度低和骨组织退化,特别是小梁数量减少和皮质骨厚度下降,以及孔隙率增加,这主要是由于骨吸收和形成之间的不平衡。结果,它增加了骨骼的脆性,增加了骨折的易感性,尤其是在老年人中。目的是评估双能X射线吸收仪(DXA)扫描在监测骨质疏松症治疗反应方面的有效性,并比较该扫描对不同骨质疏松症疗法的反应。这项回顾性队列研究包括从300名诊断为骨质疏松症的患者中选择的51名成年人,这些患者的T评分为-2.5,符合世界卫生组织(世界卫生组织)的诊断标准。数据是从2016年至2019年间阿拉伯联合酋长国迪拜一家私人医院的电子医疗记录中获取的。该研究包括社会人口学特征、生物医学参数、合并症、骨折史、药物、实验室和DXA扫描结果。94%的患者是女性;平均(±SD)年龄为58.1±11.5岁。大多数患者为外籍(84.3%),其中亚裔为66.7%。骨质疏松症的平均(±SD)持续时间为2.82±1.8年。11名(21.6%)患者有脆性骨折病史。96%的患者缺乏维生素D。三分之一(29.4%)的患者患有甲状旁腺功能亢进症。9名患者(17.6%)接受阿仑膦酸盐/胆钙化醇治疗,研究组股骨颈骨密度显著改善(p=0.018)。总之,与其他药物相比,DXA扫描作为监测工具显示,接受阿仑膦酸盐/胆钙化醇治疗的患者股骨颈BMD显著改善。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The Use of Bone Density Scan in Monitoring Treatment Response in Patients Diagnosed with Osteoporosis: A Retrospective Cohort Study.

Osteoporosis is characterized as a metabolic bone disease defined by low bone mineral density (BMD) and bone tissue degeneration, particularly a reduction in the number of trabeculae and a drop in cortical bone thickness, and a rise in porosity, which is mainly due to an imbalance between bone resorption and formation. As a result, it increases bone fragility, and the susceptibility to fracture increases, especially among the elderly. The objective is to assess the effectiveness of dual-energy X-ray absorptiometry (DXA) scan in monitoring the response to osteoporosis treatment and compare the scan's response to different osteoporosis treatments. This retrospective cohort study included 51 adults selected from 300 patients diagnosed with osteoporosis based on World Health Organization (WHO) diagnostic criteria of a T-score of -2.5. Data were acquired from the electronic medical records between 2016 and 2019 from a private hospital in Dubai, United Arab Emirates (UAE). The study included sociodemographic characteristics, biomedical parameters, comorbidities, history of fracture, medications, laboratory, and DXA scan results. Ninety-four percent of the patients were females; the mean (±SD) age was 58.1 ± 11.5 years. Most patients were expatriates (84.3%), of which Asian ethnicity was 66.7%. The mean (±SD) duration of osteoporosis was 2.82 ± 1.8 years. Eleven (21.6%) patients had a history of fragility fracture. Ninety-six percent of the patients had vitamin D deficiency. One-third (29.4%) of the patients had hyperparathyroidism. Alendronate/cholecalciferol, received by nine patients (17.6%), showed a significant improvement (p = 0.018) in the BMD of the femoral neck among the study group. In conclusion, the DXA scan as a monitoring tool has shown a significant improvement in the BMD of the femoral neck among patients taking alendronate/cholecalciferol treatment compared to other medications.

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CiteScore
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发文量
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审稿时长
24 weeks
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