NRP1在恶性肿瘤中的综合分析为治疗感染SARS-CoV-2的癌症患者提供了治疗意义。

IF 2.1 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemical Genetics Pub Date : 2023-11-08 DOI:10.1007/s10528-023-10518-2
Shuzhao Chen, Limei Zhang, Yiling Song, Kunying Xie, Yun Wang, Yang Liang
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引用次数: 0

摘要

新冠肺炎(2019冠状病毒病)由严重急性呼吸综合征冠状病毒2引起,可导致肺炎、细胞因子风暴和淋巴细胞减少。由于免疫抑制,癌症患者更容易感染SARS-CoV-2和严重的新冠肺炎。最近的研究表明,NRP1(Neuropilin 1)可能是严重急性呼吸系统综合征冠状病毒2型进入宿主细胞的新介质。由于尚未对全癌患者NRP1的特征进行系统研究,我们对全癌病人的NRP1进行了全面分析。使用生物信息学方法,我们旨在系统地检测NRP1在泛癌和健康组织中的表达谱。我们发现,与其他癌症患者相比,肺癌和泌尿生殖系统癌症的NRP-1表达相对较高,这表明这些患者可能更容易感染SARS-CoV-2。我们的分析进一步表明,NRP1在感染严重急性呼吸系统综合征冠状病毒2型的Vero E6细胞、全血、肺类器官、睾丸组织和肺泡中的表达下调。值得注意的是,在大多数癌症患者中,NRP1与免疫细胞浸润、免疫检查点基因和免疫相关基因相关。这些发现表明,在患有特定类型癌症的患者中,尤其是肺和泌尿生殖系统的患者,NRP1的高表达有助于增加对SARS-CoV-2感染的易感性,并增加因细胞因子风暴而受损的风险。总的来说,NRP1似乎在许多肿瘤类型的免疫特性和代谢调节中发挥着关键作用。NRP1抗原的特异性抑制剂(pegaptanib、EG00229或MNRP1685A)与其他抗严重急性呼吸系统综合征冠状病毒2型策略相结合,可能有助于治疗严重急性呼吸系冠状病毒2型感染后的肺癌和泌尿生殖癌患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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A Comprehensive Analysis of NRP1 in Malignancies Provide Therapeutic Implication for Treating Cancer Patients Infected with SARS-CoV-2

COVID-19 (Coronavirus disease 2019) is caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2), which can lead to pneumonia, cytokine storms, and lymphopenia. Patients with cancer are more susceptible to SARS-CoV-2 infection and severe COVID-19 due to immunosuppression. Recent studies have indicated that NRP1 (Neuropilin 1) may act as a novel mediator of SARS-CoV-2 entry into the host cell. As no systematic review has been performed investigating the characteristics of NRP1 in pan-carcinoma, we comprehensively analyzed NRP1 in patients with pan-cancer. Using a bioinformatics approach, we aimed to systematically examine NRP1 expression profiles in both pan-carcinoma and healthy tissues. We found that lung and genitourinary cancers have a relatively higher NRP-1 expression than other cancer patients, suggesting that these patients may be more susceptible to SARS-CoV-2. Our analysis further revealed that NRP1 expression was downregulated in Vero E6 cells, whole blood, lung organoids, testis tissue, and alveolospheres infected with SARS-CoV-2. Notably, NRP1 was associated with immune cell infiltration, immune checkpoint genes, and immune-related genes in most patients with cancer. These findings suggest that, in patients with specific types of cancer, especially lung and genitourinary, high expression of NRP1 contributes to greater susceptibility to SARS-CoV-2 infection and an increased risk of damage due to cytokine storms. Overall, NRP1 appears to play a critical role in regulating immunological properties and metabolism in many tumor types. Specific inhibitors of the NRP1 antigen (pegaptanib, EG00229, or MNRP1685A) combined with other anti-SARS-CoV-2 strategies may aid in treating patients with lung and genitourinary cancers following SARS-CoV-2 infection.

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来源期刊
Biochemical Genetics
Biochemical Genetics 生物-生化与分子生物学
CiteScore
3.90
自引率
0.00%
发文量
133
审稿时长
4.8 months
期刊介绍: Biochemical Genetics welcomes original manuscripts that address and test clear scientific hypotheses, are directed to a broad scientific audience, and clearly contribute to the advancement of the field through the use of sound sampling or experimental design, reliable analytical methodologies and robust statistical analyses. Although studies focusing on particular regions and target organisms are welcome, it is not the journal’s goal to publish essentially descriptive studies that provide results with narrow applicability, or are based on very small samples or pseudoreplication. Rather, Biochemical Genetics welcomes review articles that go beyond summarizing previous publications and create added value through the systematic analysis and critique of the current state of knowledge or by conducting meta-analyses. Methodological articles are also within the scope of Biological Genetics, particularly when new laboratory techniques or computational approaches are fully described and thoroughly compared with the existing benchmark methods. Biochemical Genetics welcomes articles on the following topics: Genomics; Proteomics; Population genetics; Phylogenetics; Metagenomics; Microbial genetics; Genetics and evolution of wild and cultivated plants; Animal genetics and evolution; Human genetics and evolution; Genetic disorders; Genetic markers of diseases; Gene technology and therapy; Experimental and analytical methods; Statistical and computational methods.
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