乳腺良恶性疾病患者血清miR-181a和miR-25。

Q3 Biochemistry, Genetics and Molecular Biology Biomeditsinskaya khimiya Pub Date : 2023-11-01 DOI:10.18097/PBMC20236905307

M L Perepechaeva, A A Studenikina, A Yu Grishanova, A N Glushkov, E G Polenok, P V Bajramov, A I Autenshlyus

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引用次数: 0

摘要

乳腺肿瘤疾病包括广泛的病理学，需要不同的治疗方法。微小RNA（miR）水平反映了参与肿瘤发生的基因表达的调节，可以作为乳腺疾病的诊断和预后标志物。循环miR-181a和miR-25的水平在良性乳腺疾病（BBD）患者、非特异性浸润性癌（ICNT）患者以及有条件健康的女性中进行了测量。与对照组相比，两组患者的两种miR的表达均较高；同时，BBD患者血清miR-181a和miR-25的含量高于ICNT患者。检测到的变化可能与BBD的癌前变化有关。作为大型诊断小组的一部分，在未来将其用作病理过程的标志物似乎是可能的。

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Serum miR-181a and miR-25 in patients with malignant and benign breast diseases.

Breast tumor diseases include a wide range of pathologies that require different approaches to their treatment. MicroRNA (miR) levels, reflecting regulation of the gene expression involved in tumorigenesis, can be diagnostic and prognostic markers of breast diseases. The levels of circulating miR-181a and miR-25 were measured in patients with benign breast diseases (BBD), patients with invasive carcinoma of a nonspecific type (ICNT) and also in conditionally healthy women. Expression of both miRs was higher in patients of both groups as compared to controls; at the same time, the content of serum miR-181a and miR-25 was higher in BBD patients than in ICNT patients. The detected changes may be of interest in the context of precancerous changes in BBD. It seems possible to use them in the future as markers of the pathological process as a part of a large diagnostic panel.

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来源期刊

Biomeditsinskaya khimiya Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： The aim of the Russian-language journal "Biomeditsinskaya Khimiya" (Biomedical Chemistry) is to introduce the latest results obtained by scientists from Russia and other Republics of the Former Soviet Union. The Journal will cover all major areas of Biomedical chemistry, including neurochemistry, clinical chemistry, molecular biology of pathological processes, gene therapy, development of new drugs and their biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine etc. The Journal also publish review articles. All issues of journal usually contain invited reviews. Papers written in Russian contain abstract (in English).