L-甲硫氨酸通过调节氧化还原状态和炎症来预防甲氨蝶呤诱导的肾毒性。

IF 5.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Redox Report Pub Date : 2023-12-01 Epub Date: 2023-11-06 DOI:10.1080/13510002.2023.2270886
Wessam M Abdel-Wahab, Nada S Daifalla, Amina E Essawy
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引用次数: 0

摘要

目的:甲氨蝶呤(MTX)是治疗癌症和自身免疫性疾病的药物;然而,由于包括肾毒性在内的严重副作用,其临床应用受到限制。本研究旨在探讨蛋氨酸(L-Met)对MTX对大鼠肾脏毒性的保护作用。方法:30只雄性大鼠平均分为5组:对照组(生理盐水)、Met400(400mg/kg L-Met)、MTX(20mg/kg MTX)、MTX-Met300(300mg/kg L-Met20 mg/kg MTX)和MTX-Met400(400 mg/kg L-Met20 mg/kgMTX)。在最后一次给药后一天(第16天)对大鼠实施安乐死,并收集血清和肾组织样本。评估肾功能和损伤指数、氧化应激/抗氧化指数和促炎细胞因子。结果:L-Met可以通过改善大多数测试参数,以剂量相关的方式有效对抗MTX的肾毒性作用。此外,更高剂量的L-Met能够将几个参数恢复到正常水平。此外,对MTX诱导的血液学变化的研究揭示了L-Met的纠正潜力。结论:L-Met具有抗氧化和抗炎作用,是调节MTX相关肾毒性的有效辅助疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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L-methionine protects against nephrotoxicity induced by methotrexate through modulation of redox status and inflammation.

Objective: Methotrexate (MTX) is a drug used in the treatment of cancer and autoimmune disorders; however, its clinical use is limited because of serious side effects including renal toxicity. This study aimed to investigate the protective effect of Lmethionine (L-Met) on MTX toxicity in the kidneys of rats.Methods: Thirty male rats were divided equally into five groups: control (saline), Met400 (400 mg/kg L-Met), MTX (20 mg/kg MTX), MTX-Met300 (300 mg/kg L-Met and 20 mg/kg MTX), and MTX-Met400 (400 mg/kg L-Met and 20 mg/kg MTX). Rats were euthanized one day after the last dose administration (day 16) and serum and renal tissue samples were collected. Renal function and injury indices, oxidative stress/antioxidant indices and proinflammatory cytokines were evaluated.Results: The results showed that L-Met could effectively counteract the nephrotoxic effects of MTX, in a dose-related manner, by improving most of the tested parameters. Furthermore, the higher dose of L-Met was able to restore several parameters to normal levels. In addition, investigation of MTX-induced hematological changes revealed a corrective potential of L-Met.Conclusion: L-Met can be an effective adjuvant therapy to modulate renal toxicity associated with MTX because of its antioxidant and antiinflammatory effects.

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来源期刊
Redox Report
Redox Report 生物-生化与分子生物学
CiteScore
6.10
自引率
0.00%
发文量
28
审稿时长
>12 weeks
期刊介绍: Redox Report is a multidisciplinary peer-reviewed open access journal focusing on the role of free radicals, oxidative stress, activated oxygen, perioxidative and redox processes, primarily in the human environment and human pathology. Relevant papers on the animal and plant environment, biology and pathology will also be included. While emphasis is placed upon methodological and intellectual advances underpinned by new data, the journal offers scope for review, hypotheses, critiques and other forms of discussion.
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