一例低镁血症引起的小脑综合征的非典型病例并文献复习。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-12-01 Epub Date: 2023-11-07 DOI:10.1177/14782715231209776
Madhugandha Wahane, Himanshu Kaushal, Gaurav Goyal, Mukesh Sarna
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引用次数: 0

摘要

成人小脑共济失调一直是一个诊断挑战。迟发性小脑共济失调的重要原因之一是低镁血症。低镁血症有多种表现,可归因于多种原因。HiCS(低镁血症诱导的小脑综合征)的鉴定很重要,因为它是可逆的,但经常被遗漏。HiCS具有独特的临床表现和特征性磁共振成像(MRI)表现。HiCS表现出不同的临床、生化和神经影像学表现,但即使没有神经影像学结果,也不能排除。这种情况必须及时仔细地治疗,以避免引发任何严重并发症,诊断时需要强烈怀疑。应评估和处理潜在原因,因为HiCS是一种严重但潜在可逆的疾病,预后良好。我们报告了一例有复发性共济失调、震颤和眩晕病史的HiCS患者,经治疗后病情有所好转。我们的患者是非典型的,因为没有明显的MRI结果可归因于低镁血症。全世界只有七份病例报告显示了这种差异。
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An atypical case of hypomagnesemia-induced cerebellar syndrome with literature review.

Cerebellar ataxia in adults is always a diagnostic challenge. One of the important causes of late-onset cerebellar ataxia is hypomagnesemia. Hypomagnesemia can have varied manifestations and is attributable to numerous causes. Identification of hypomagnesemia-induced cerebellar syndrome (HiCS) is important as it is reversible but often missed. HiCS has distinct clinical findings and characteristic magnetic resonance imaging (MRI) findings. HiCS presents with distinct clinical, biochemical, and neuroimaging findings, but it cannot be ruled out even in the absence of neuroimaging findings. This condition has to be treated promptly and meticulously to avoid precipitating any serious complications, and a strong suspicion is required for the diagnosis. The underlying cause should be evaluated and managed, as HiCS is a serious but potentially reversible disease with a good prognosis. We present a case of HiCS presenting with a characteristic history of recurrent ataxia, tremor, and vertigo that improved with treatment. Our patient was atypical, as there were no significant MRI findings attributable to hypomagnesemia. Only seven case reports are available throughout the world that show such disparity.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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