老年抑郁症患者血细胞中能量、谷氨酸和谷胱甘肽代谢酶的活性

IF 2.5 4区 医学 Q2 PSYCHIATRY European Journal of Psychiatry Pub Date : 2022-10-01 DOI:10.1016/j.ejpsy.2022.05.001
Olga Savushkina , Irina Boksha , Tatyana Prokhorova , Elena Tereshkina , Tatyana Safarova , Olga Yakovleva , Vladimir Kornilov , Elena Shipilova , Elena Vorobyeva , Gulnur Burbaeva
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引用次数: 2

摘要

老年人抑郁症的异质性是发展以人为中心的治疗的挑战。为了解决这个问题,我们研究了53名老年抑郁症患者和20名对照者血细胞中的谷氨酸和谷胱甘肽代谢酶。抑郁症患者血小板谷胱甘肽-S-转移酶和红细胞谷胱甘肽还原酶降低。生化和临床数据促成了三个临床集群,这些集群与抑郁症的发作或持续时间无关,但与焦虑、脑血管和心血管合并症有关,包括帕金森氏症特征,如震颤、静坐障碍和强直。这些发现有助于以人为中心的诊断和结果,并及时成功治疗老年人的抑郁症。
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Activity of energy, glutamate, and glutathione metabolism enzymes in blood cells of elderly patients with depression

Heterogeneity of depression in older adults is a challenge for the development of person-centered treatment. To address this, we studied glutamate and glutathione metabolism enzymes in blood cells in 53 older adult patients with depression and 20 controls. Patients with depression had decreased platelet glutathione-S-transferase and erythrocyte glutathione reductase. The biochemical and clinical data contributed to three clinical clusters that are not linked to the onset of depression or its duration but were related to anxiety, cerebrovascular and cardiovascular comorbidities, including parkinsonian features such as tremor, akathisia, and rigidity. These findings could aid person-centered diagnosis and outcomes and timely successful treatment(s) of depression in older adults.

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来源期刊
CiteScore
2.90
自引率
0.00%
发文量
40
审稿时长
43 days
期刊介绍: The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.
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