Leticia González-Blanco , Carlota Moya-Lacasa , Sara Jiménez-Fernández , Clara Martínez-Cao , Mercedes Valtueña-García , Francesco Dal Santo , M. Paz García-Portilla , Luis Gutiérrez-Rojas
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The search strategy was: (\"peripheral biomarkers\" OR \"biological markers\" OR biomarker OR cortisol OR melatonin OR orexin OR hypocretin) AND (blood OR serum OR plasma) AND (“sleep-wake” OR \"circadian rhythm\" OR sleep OR insomnia) AND \"bipolar.\"</p></div><div><h3>Results</h3><p>After excluding duplicates, 92 records were obtained. Only 5 studies met the inclusion criteria (n=499; bipolar disorder=125; unipolar depression=148; schizophrenia=80; controls=146). The endocrine parameters analyzed were: cortisol (3 studies), melatonin (1 study), and orexin-A (1 study). Overall, no significant associations were detected between these biomarkers and sleep disturbances, assessed with subjective (psychometric evaluation) and/or objective (polysomnography) measures.</p></div><div><h3>Conclusion</h3><p>This review highlights the lack of studies exploring the role of endocrine biomarkers related to circadian function in the pathophysiology of sleep disturbances in bipolar disorder.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"36 4","pages":"Pages 223-229"},"PeriodicalIF":2.5000,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0213616322000362/pdfft?md5=5b0cef2bba191818994f6adaf0af170b&pid=1-s2.0-S0213616322000362-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Endocrine biomarkers related to sleep-wake cycle and sleep disturbances in patients with bipolar disorder: A systematic review\",\"authors\":\"Leticia González-Blanco , Carlota Moya-Lacasa , Sara Jiménez-Fernández , Clara Martínez-Cao , Mercedes Valtueña-García , Francesco Dal Santo , M. Paz García-Portilla , Luis Gutiérrez-Rojas\",\"doi\":\"10.1016/j.ejpsy.2022.04.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and objectives</h3><p>Sleep and circadian disturbances have been widely studied in patients with bipolar disorder. However, there is no clear evidence about the role of peripheral biomarkers of the circadian cycle in this population. This systematic review aims to identify potential endocrine blood biomarkers of circadian rhythms and study their relationship with sleep problems in these patients.</p></div><div><h3>Methods</h3><p>An electronic search was performed of PubMed and PsycINFO databases. It included articles about the topic from 1991 through 2021. 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Endocrine biomarkers related to sleep-wake cycle and sleep disturbances in patients with bipolar disorder: A systematic review
Background and objectives
Sleep and circadian disturbances have been widely studied in patients with bipolar disorder. However, there is no clear evidence about the role of peripheral biomarkers of the circadian cycle in this population. This systematic review aims to identify potential endocrine blood biomarkers of circadian rhythms and study their relationship with sleep problems in these patients.
Methods
An electronic search was performed of PubMed and PsycINFO databases. It included articles about the topic from 1991 through 2021. The search strategy was: ("peripheral biomarkers" OR "biological markers" OR biomarker OR cortisol OR melatonin OR orexin OR hypocretin) AND (blood OR serum OR plasma) AND (“sleep-wake” OR "circadian rhythm" OR sleep OR insomnia) AND "bipolar."
Results
After excluding duplicates, 92 records were obtained. Only 5 studies met the inclusion criteria (n=499; bipolar disorder=125; unipolar depression=148; schizophrenia=80; controls=146). The endocrine parameters analyzed were: cortisol (3 studies), melatonin (1 study), and orexin-A (1 study). Overall, no significant associations were detected between these biomarkers and sleep disturbances, assessed with subjective (psychometric evaluation) and/or objective (polysomnography) measures.
Conclusion
This review highlights the lack of studies exploring the role of endocrine biomarkers related to circadian function in the pathophysiology of sleep disturbances in bipolar disorder.
期刊介绍：
The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.
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