印度北部查谟地区Dogra人群中toll样受体2基因多态性(rs3804099)与精神分裂症易感性的关系

IF 2.5 4区 医学 Q2 PSYCHIATRY European Journal of Psychiatry Pub Date : 2022-04-01 DOI:10.1016/j.ejpsy.2022.02.001
Isar Sharma , Indu Priya , Sakshi Sharma , Suruchi Gupta , Manu Arora , Ritu Mahajan , Nisha Kapoor
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引用次数: 3

摘要

背景与目的精神分裂症(SCZ)是一种严重的精神生物学障碍,具有与环境、发育和遗传相关的多因素传播和遗传方式。这是一种可遗传的疾病,涉及基因和代谢机制的综合作用,每种作用都会使整体疾病负担略有增加。尽管最近的研究表明SCZ与炎症之间存在关系,但其病因尚不完全清楚。来自各种研究的证据表明,TLR基因的失调可能在精神分裂症的病理生理学中发挥作用。在本研究中,研究了TLR1、TLR2、TLR4和TLR6中的4个多态性,以探索它们在查谟地区多格拉人群对SCZ易感性中的作用。方法500名个体,包括200名SCZ和300名健康对照。分离DNA,并在PCR扩增后进行Sanger测序。结果在研究人群中观察到TLR2(rs3804099)的统计学显著相关性,rs380409的C等位基因与SCZ风险增加相关(OR=2.667;[1.4196–5.0093,95%CI]P=0.0023)。在TLR1、TLR4、,结论TLR2(rs3804099)可能与目标人群中的精神分裂症有关。可以进行深入的研究,重点是寻找潜在的SNPs来建立候选基因方法。
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Association of toll-like receptor 2 gene polymorphism (rs3804099) with susceptibility to Schizophrenia risk in the Dogra population of Jammu region, North India

Background and objective

Schizophrenia (SCZ) is a severe mental biological disorder with a multifactorial manner of transmission and inheritance associated with environmental, developmental, and genetic set-off. It is a heritable disorder that involves genes and metabolic mechanisms in a combined effect, each conferring a small increase in the overall disease burden. Its etiology is not fully understood, although recent studies showed a relationship between SCZ and inflammation. Evidence from various studies indicates that dysregulation of TLR genes may have a role in the physiopathology of schizophrenia. In the present study, 4 polymorphisms, each in TLR1, TLR2, TLR4, and TLR6, were studied to explore their role in susceptibility to SCZ in the Dogra population of the Jammu region.

Methods

Five hundred (500) individuals including 200 SCZ and 300 healthy controls were included in the study. DNA was isolated and Sanger's sequencing was performed after PCR amplification.

Results

Statistically significant association of TLR2 (rs3804099) was observed in the study population, the C allele of rs3804099 is associated with the increased risk for SCZ (OR=2.667; [1.4196–5.0093 at 95%CI] P = 0.0023). No statistically significant associations with SCZ were observed in the target population at TLR1, TLR4, and TLR6.

Conclusion

Study concludes that TLR2 (rs3804099) may be associated with schizophrenia in the targeted population. Advance studies can be carried out focusing on finding potential SNPs for establishing a candidate gene approach.

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来源期刊
CiteScore
2.90
自引率
0.00%
发文量
40
审稿时长
43 days
期刊介绍: The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.
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