炎症相关血浆蛋白与学龄前急性喘息的关系

IF 4.6 2区 医学 Q2 ALLERGY Clinical and Translational Allergy Pub Date : 2023-11-01 DOI:10.1002/clt2.12308
Idun Holmdahl, Sandip Chakraborty, Angela Hoyer, Anastasia Filiou, Anna Asarnoj, Anders Sjölander, Magnus P. Borres, Marianne van Hage, Gunilla Hedlin, Jon R. Konradsen, Cilla Söderhäll
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引用次数: 0

摘要

背景学龄前喘息是哮喘发展的危险因素。然而,喘息发作背后的分子机制尚不清楚。目的我们的目的是评估血浆蛋白与学龄前急性喘息的关系,并研究3个月后复查时急性期差异表达的蛋白。此外,研究蛋白质表达与临床参数之间的关系。方法在GEWAC队列中,我们使用抗体介导的基于邻近延伸的测定法(Olink Proteomics,Uppsala)测量了145名学龄前喘息(PW)发作期间和3个月后再次就诊时(PW-R,n=113/145)儿童和101名6–48个月的健康对照(HC)的血浆中的92种炎症蛋白和临床参数结果在74个分析的蛋白质中,52个在PW和HC之间有差异表达。前10种蛋白质,肿瘤学抑制素M(OSM)、IL-10、IL-6、成纤维细胞生长因子21(FGF21)、AXIN1、CXCL10、SIRT2、TNFSF11、肿瘤坏死因子β(TNF-β)和CASP8的表达谱几乎可以完全分离PW和HC。10种蛋白质中有5种与采血前24小时口服皮质类固醇(OCS)的摄入有关(OSM、CASP8、IL-10、TNF-β和CXCL10)。与HC相比,患有或不患有OCS的PWs之间的蛋白质表达没有差异。在3个月后的复查中,10种蛋白质中的三种(IL-10、SIRT2和FGF21)在PW-R和HC之间仍然存在差异蛋白表达。结论我们的研究结果有助于揭示学龄前喘息和哮喘之间潜在的免疫病理通路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Inflammatory related plasma proteins involved in acute preschool wheeze

Background

Preschool wheeze is a risk factor for asthma development. However, the molecular mechanism behind a wheezing episode is not well understood.

Objective

Our aims were to assess the association of plasma proteins with acute preschool wheeze and to study the proteins with differential expression at the acute phase at revisit after 3 months. Additionally, to investigate the relationship between protein expression and clinical parameters.

Method

We measured 92 inflammatory proteins in plasma and clinical parameters from 145 children during an episode of preschool wheeze (PW) and at the revisit after 3 months (PW-R, n = 113/145) and 101 healthy controls (HC) aged 6–48 months in the GEWAC cohort using the antibody-mediated proximity extension-based assay (Olink Proteomics, Uppsala).

Results

Of the 74 analysed proteins, 52 were differentially expressed between PW and HC. The expression profiles of the top 10 proteins, Oncostatin M (OSM), IL-10, IL-6, Fibroblast growth factor 21 (FGF21), AXIN1, CXCL10, SIRT2, TNFSF11, Tumour necrosis factor β (TNF-β) and CASP8, could almost entirely separate PW from HC. Five out of 10 proteins were associated with intake of oral corticosteroids (OCS) 24 h preceding blood sampling (OSM, CASP8, IL-10, TNF-β and CXCL10). No differences in protein expression were seen between PWs with or without OCS in comparison to HC. At the revisit after 3 months, differential protein expressions were still seen between PW-R and HC for three (IL-10, SIRT2 and FGF21) of the 10 proteins.

Conclusion

Our results contribute to unravelling potential immunopathological pathways shared between preschool wheeze and asthma.

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来源期刊
Clinical and Translational Allergy
Clinical and Translational Allergy Immunology and Microbiology-Immunology
CiteScore
7.50
自引率
4.50%
发文量
117
审稿时长
12 weeks
期刊介绍: Clinical and Translational Allergy, one of several journals in the portfolio of the European Academy of Allergy and Clinical Immunology, provides a platform for the dissemination of allergy research and reviews, as well as EAACI position papers, task force reports and guidelines, amongst an international scientific audience. Clinical and Translational Allergy accepts clinical and translational research in the following areas and other related topics: asthma, rhinitis, rhinosinusitis, drug hypersensitivity, allergic conjunctivitis, allergic skin diseases, atopic eczema, urticaria, angioedema, venom hypersensitivity, anaphylaxis, food allergy, immunotherapy, immune modulators and biologics, animal models of allergic disease, immune mechanisms, or any other topic related to allergic disease.
期刊最新文献
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