Melissa J. Green, Kirstie O’Hare, Kristin R. Laurens, Stacy Tzoumakis, Kimberlie Dean, Johanna C. Badcock, Felicity Harris, Richard J. Linscott, Vaughan J. Carr
{"title":"普通人群中精神分裂症的发展概况:澳大利亚11-12岁儿童的记录关联研究 年","authors":"Melissa J. Green, Kirstie O’Hare, Kristin R. Laurens, Stacy Tzoumakis, Kimberlie Dean, Johanna C. Badcock, Felicity Harris, Richard J. Linscott, Vaughan J. Carr","doi":"10.1111/bjc.12363","DOIUrl":null,"url":null,"abstract":"<div>\n \n <section>\n \n <h3> Objectives</h3>\n \n <p>The detection of young people at high risk for psychotic disorders has been somewhat narrowly focused on overt symptom-based markers that reflect mild reality distortion (e.g., psychotic-like experiences), or prodromal syndromes that are proximal to psychosis onset. The concept of schizotypy represents a broader framework for investigating risk for schizophrenia (and other disorders) in childhood, before the onset of prodromal or overt symptoms. We sought to detect profiles of risk for psychosis (schizotypy) in a general population sample of 22,137 Australian children aged 11–12 years, and to determine early life risk factors associated with these profiles from data available in linked records (registers).</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Fifty-nine self-reported items were used as indicators of schizotypy across six broad domains; <i>z</i>-scores for each domain were subjected to latent profile analyses (LPA). A series of multinomial logistic regressions was used to examine the association between resulting profile (class) membership and several childhood and parental risk factors, and the proportion of children with mental disorders among each schizotypy profile was examined.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The LPA revealed three person-centred profiles referred to as <i>True Schizotypy</i> (<i>n</i> = 1,323; 6.0%), <i>Introverted Schizotypy</i> (<i>n</i> = 4,473; 20.2%), and <i>Affective Schizotypy</i> (<i>n</i> = 4,261; 19.2%), as well as a group of children showing no risk (<i>n</i> = 12,080; 54.6%). Prior exposure to perinatal and familial adversities including childhood maltreatment, as well as poor early childhood development and academic functioning, was variously associated with all risk groups. There was a higher proportion of childhood mental disorder diagnoses among children in the <i>True Schizotypy</i> group, relative to other profiles.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Subtle differences in the pattern of exposures and antecedents among schizophrenia liability profiles in childhood may reflect distinct pathogenic pathways to psychotic or other mental illness.</p>\n </section>\n \n <section>\n \n <h3> Practitioner points</h3>\n \n <div>\n \n <ul>\n \n \n <li>Children aged 11–12 years report characteristics of schizotypy which can be classified into three distinct profiles that may represent different pathological processes towards later mental ill-health.</li>\n \n \n <li>Early life exposure to perinatal and familial adversities including childhood maltreatment, early childhood developmental vulnerability, and poor academic functioning predict membership in all three childhood schizotypy profiles.</li>\n \n \n <li>Latent liability for schizophrenia (and potentially other mental disorders) may be represented by different profiles of functioning observable in childhood.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":48211,"journal":{"name":"British Journal of Clinical Psychology","volume":"61 3","pages":"836-858"},"PeriodicalIF":3.8000,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://bpspsychub.onlinelibrary.wiley.com/doi/epdf/10.1111/bjc.12363","citationCount":"3","resultStr":"{\"title\":\"Developmental profiles of schizotypy in the general population: A record linkage study of Australian children aged 11–12 years\",\"authors\":\"Melissa J. 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We sought to detect profiles of risk for psychosis (schizotypy) in a general population sample of 22,137 Australian children aged 11–12 years, and to determine early life risk factors associated with these profiles from data available in linked records (registers).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Fifty-nine self-reported items were used as indicators of schizotypy across six broad domains; <i>z</i>-scores for each domain were subjected to latent profile analyses (LPA). A series of multinomial logistic regressions was used to examine the association between resulting profile (class) membership and several childhood and parental risk factors, and the proportion of children with mental disorders among each schizotypy profile was examined.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The LPA revealed three person-centred profiles referred to as <i>True Schizotypy</i> (<i>n</i> = 1,323; 6.0%), <i>Introverted Schizotypy</i> (<i>n</i> = 4,473; 20.2%), and <i>Affective Schizotypy</i> (<i>n</i> = 4,261; 19.2%), as well as a group of children showing no risk (<i>n</i> = 12,080; 54.6%). Prior exposure to perinatal and familial adversities including childhood maltreatment, as well as poor early childhood development and academic functioning, was variously associated with all risk groups. There was a higher proportion of childhood mental disorder diagnoses among children in the <i>True Schizotypy</i> group, relative to other profiles.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Subtle differences in the pattern of exposures and antecedents among schizophrenia liability profiles in childhood may reflect distinct pathogenic pathways to psychotic or other mental illness.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Practitioner points</h3>\\n \\n <div>\\n \\n <ul>\\n \\n \\n <li>Children aged 11–12 years report characteristics of schizotypy which can be classified into three distinct profiles that may represent different pathological processes towards later mental ill-health.</li>\\n \\n \\n <li>Early life exposure to perinatal and familial adversities including childhood maltreatment, early childhood developmental vulnerability, and poor academic functioning predict membership in all three childhood schizotypy profiles.</li>\\n \\n \\n <li>Latent liability for schizophrenia (and potentially other mental disorders) may be represented by different profiles of functioning observable in childhood.</li>\\n </ul>\\n </div>\\n </section>\\n </div>\",\"PeriodicalId\":48211,\"journal\":{\"name\":\"British Journal of Clinical Psychology\",\"volume\":\"61 3\",\"pages\":\"836-858\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2022-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://bpspsychub.onlinelibrary.wiley.com/doi/epdf/10.1111/bjc.12363\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"British Journal of Clinical Psychology\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/bjc.12363\",\"RegionNum\":3,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHOLOGY, CLINICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"British Journal of Clinical Psychology","FirstCategoryId":"102","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/bjc.12363","RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHOLOGY, CLINICAL","Score":null,"Total":0}
Developmental profiles of schizotypy in the general population: A record linkage study of Australian children aged 11–12 years
Objectives
The detection of young people at high risk for psychotic disorders has been somewhat narrowly focused on overt symptom-based markers that reflect mild reality distortion (e.g., psychotic-like experiences), or prodromal syndromes that are proximal to psychosis onset. The concept of schizotypy represents a broader framework for investigating risk for schizophrenia (and other disorders) in childhood, before the onset of prodromal or overt symptoms. We sought to detect profiles of risk for psychosis (schizotypy) in a general population sample of 22,137 Australian children aged 11–12 years, and to determine early life risk factors associated with these profiles from data available in linked records (registers).
Methods
Fifty-nine self-reported items were used as indicators of schizotypy across six broad domains; z-scores for each domain were subjected to latent profile analyses (LPA). A series of multinomial logistic regressions was used to examine the association between resulting profile (class) membership and several childhood and parental risk factors, and the proportion of children with mental disorders among each schizotypy profile was examined.
Results
The LPA revealed three person-centred profiles referred to as True Schizotypy (n = 1,323; 6.0%), Introverted Schizotypy (n = 4,473; 20.2%), and Affective Schizotypy (n = 4,261; 19.2%), as well as a group of children showing no risk (n = 12,080; 54.6%). Prior exposure to perinatal and familial adversities including childhood maltreatment, as well as poor early childhood development and academic functioning, was variously associated with all risk groups. There was a higher proportion of childhood mental disorder diagnoses among children in the True Schizotypy group, relative to other profiles.
Conclusion
Subtle differences in the pattern of exposures and antecedents among schizophrenia liability profiles in childhood may reflect distinct pathogenic pathways to psychotic or other mental illness.
Practitioner points
Children aged 11–12 years report characteristics of schizotypy which can be classified into three distinct profiles that may represent different pathological processes towards later mental ill-health.
Early life exposure to perinatal and familial adversities including childhood maltreatment, early childhood developmental vulnerability, and poor academic functioning predict membership in all three childhood schizotypy profiles.
Latent liability for schizophrenia (and potentially other mental disorders) may be represented by different profiles of functioning observable in childhood.
期刊介绍:
The British Journal of Clinical Psychology publishes original research, both empirical and theoretical, on all aspects of clinical psychology: - clinical and abnormal psychology featuring descriptive or experimental studies - aetiology, assessment and treatment of the whole range of psychological disorders irrespective of age group and setting - biological influences on individual behaviour - studies of psychological interventions and treatment on individuals, dyads, families and groups