Fernanda de Toledo Gonçalves , Lucas Murrins Marques , Anne Victório Pessotto , Sara Pinto Barbosa , Marta Imamura , Marcel Simis , Felipe Fregni , Linamara Battistella
{"title":"OPRM1和BDNF多态性与膝骨关节炎患者的代偿性神经生理学特征相关。","authors":"Fernanda de Toledo Gonçalves , Lucas Murrins Marques , Anne Victório Pessotto , Sara Pinto Barbosa , Marta Imamura , Marcel Simis , Felipe Fregni , Linamara Battistella","doi":"10.1016/j.neucli.2023.102917","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>The present study investigated the relationship between three genetic polymorphisms of <em>OPRM1</em> (rs1799971 - A118G and rs1799972 - C17T) and <em>BDNF</em> (rs6265 - C196T) and EEG-measured brain oscillations in Knee Osteoarthritis (KOA) patients.</p></div><div><h3>Materials and Methods</h3><p>We performed a cross-sectional analysis of a cohort study (DEFINE cohort), KOA arm, with 66 patients, considering demographic (age, sex, and education), clinical (pain intensity and duration), <em>OPRM1</em> (rs1799971 - A118G and rs1799972 - C17T) and <em>BDNF</em> (rs6265 - C196T) genotypes, and electrophysiological measures. Brain oscillations relative power from Delta, Theta, Alpha, Low Alpha, High Alpha, Beta, Low Beta and High Beta oscillations were measured during resting state EEG. Multivariate regression models were used to explore the main brain oscillation predictors of the three genetic polymorphisms.</p></div><div><h3>Results</h3><p>Our findings demonstrate that Theta and Low Beta oscillations are associated with the variant allele of <em>OPRM1</em>-rs1799971 (A118G) on left frontal and left central regions, respectively, while Alpha brain oscillation is associated with variant genotypes (CT/TT) of <em>BDNF</em>-rs6265 on frontal (decrease of oscillation power) and left central (increase of oscillation power) regions. No significant model was found for <em>OPRM1</em>-rs1799972 (C17T) in addition to the inclusion of pain intensity as a significant predictor of this last model.</p></div><div><h3>Conclusion</h3><p>One potential interpretation for these findings is that polymorphisms of <em>OPRM1</em> – that is involved with endogenous pain control - lead to increased compensatory oscillatory mechanisms, characterized by increased theta oscillations. Along the same line, polymorphisms of the BDNF lead to decreased alpha oscillations in the frontal area, likely also reflecting the disruption of resting states to also compensate for the increased injury associated with knee OA. It is possible that these polymorphisms require additional brain adaption to the knee OA related injury.</p></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"53 6","pages":"Article 102917"},"PeriodicalIF":2.7000,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"OPRM1 and BDNF polymorphisms associated with a compensatory neurophysiologic signature in knee osteoarthritis patients\",\"authors\":\"Fernanda de Toledo Gonçalves , Lucas Murrins Marques , Anne Victório Pessotto , Sara Pinto Barbosa , Marta Imamura , Marcel Simis , Felipe Fregni , Linamara Battistella\",\"doi\":\"10.1016/j.neucli.2023.102917\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>The present study investigated the relationship between three genetic polymorphisms of <em>OPRM1</em> (rs1799971 - A118G and rs1799972 - C17T) and <em>BDNF</em> (rs6265 - C196T) and EEG-measured brain oscillations in Knee Osteoarthritis (KOA) patients.</p></div><div><h3>Materials and Methods</h3><p>We performed a cross-sectional analysis of a cohort study (DEFINE cohort), KOA arm, with 66 patients, considering demographic (age, sex, and education), clinical (pain intensity and duration), <em>OPRM1</em> (rs1799971 - A118G and rs1799972 - C17T) and <em>BDNF</em> (rs6265 - C196T) genotypes, and electrophysiological measures. Brain oscillations relative power from Delta, Theta, Alpha, Low Alpha, High Alpha, Beta, Low Beta and High Beta oscillations were measured during resting state EEG. Multivariate regression models were used to explore the main brain oscillation predictors of the three genetic polymorphisms.</p></div><div><h3>Results</h3><p>Our findings demonstrate that Theta and Low Beta oscillations are associated with the variant allele of <em>OPRM1</em>-rs1799971 (A118G) on left frontal and left central regions, respectively, while Alpha brain oscillation is associated with variant genotypes (CT/TT) of <em>BDNF</em>-rs6265 on frontal (decrease of oscillation power) and left central (increase of oscillation power) regions. No significant model was found for <em>OPRM1</em>-rs1799972 (C17T) in addition to the inclusion of pain intensity as a significant predictor of this last model.</p></div><div><h3>Conclusion</h3><p>One potential interpretation for these findings is that polymorphisms of <em>OPRM1</em> – that is involved with endogenous pain control - lead to increased compensatory oscillatory mechanisms, characterized by increased theta oscillations. Along the same line, polymorphisms of the BDNF lead to decreased alpha oscillations in the frontal area, likely also reflecting the disruption of resting states to also compensate for the increased injury associated with knee OA. It is possible that these polymorphisms require additional brain adaption to the knee OA related injury.</p></div>\",\"PeriodicalId\":19134,\"journal\":{\"name\":\"Neurophysiologie Clinique/Clinical Neurophysiology\",\"volume\":\"53 6\",\"pages\":\"Article 102917\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2023-11-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurophysiologie Clinique/Clinical Neurophysiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0987705323000746\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurophysiologie Clinique/Clinical Neurophysiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0987705323000746","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
OPRM1 and BDNF polymorphisms associated with a compensatory neurophysiologic signature in knee osteoarthritis patients
Objective
The present study investigated the relationship between three genetic polymorphisms of OPRM1 (rs1799971 - A118G and rs1799972 - C17T) and BDNF (rs6265 - C196T) and EEG-measured brain oscillations in Knee Osteoarthritis (KOA) patients.
Materials and Methods
We performed a cross-sectional analysis of a cohort study (DEFINE cohort), KOA arm, with 66 patients, considering demographic (age, sex, and education), clinical (pain intensity and duration), OPRM1 (rs1799971 - A118G and rs1799972 - C17T) and BDNF (rs6265 - C196T) genotypes, and electrophysiological measures. Brain oscillations relative power from Delta, Theta, Alpha, Low Alpha, High Alpha, Beta, Low Beta and High Beta oscillations were measured during resting state EEG. Multivariate regression models were used to explore the main brain oscillation predictors of the three genetic polymorphisms.
Results
Our findings demonstrate that Theta and Low Beta oscillations are associated with the variant allele of OPRM1-rs1799971 (A118G) on left frontal and left central regions, respectively, while Alpha brain oscillation is associated with variant genotypes (CT/TT) of BDNF-rs6265 on frontal (decrease of oscillation power) and left central (increase of oscillation power) regions. No significant model was found for OPRM1-rs1799972 (C17T) in addition to the inclusion of pain intensity as a significant predictor of this last model.
Conclusion
One potential interpretation for these findings is that polymorphisms of OPRM1 – that is involved with endogenous pain control - lead to increased compensatory oscillatory mechanisms, characterized by increased theta oscillations. Along the same line, polymorphisms of the BDNF lead to decreased alpha oscillations in the frontal area, likely also reflecting the disruption of resting states to also compensate for the increased injury associated with knee OA. It is possible that these polymorphisms require additional brain adaption to the knee OA related injury.
期刊介绍：
Neurophysiologie Clinique / Clinical Neurophysiology (NCCN) is the official organ of the French Society of Clinical Neurophysiology (SNCLF). This journal is published 6 times a year, and is aimed at an international readership, with articles written in English. These can take the form of original research papers, comprehensive review articles, viewpoints, short communications, technical notes, editorials or letters to the Editor. The theme is the neurophysiological investigation of central or peripheral nervous system or muscle in healthy humans or patients. The journal focuses on key areas of clinical neurophysiology: electro- or magneto-encephalography, evoked potentials of all modalities, electroneuromyography, sleep, pain, posture, balance, motor control, autonomic nervous system, cognition, invasive and non-invasive neuromodulation, signal processing, bio-engineering, functional imaging.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
