地衣计划和皮肤病

A. Levy (Chef de clinique) , L. Le Cleach (Praticien hospitalier)
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引用次数: 0

摘要

扁平苔藓是一种成人慢性瘙痒性皮肤病,其特征是有光泽的扁平紫红色多角形丘疹。它可能影响身体表面的任何部位,但最有可能出现在四肢的伸展部位。粘膜病变非常常见。非典型形式很常见。组织学特征是真皮浅层淋巴细胞的浅带状浸润,真皮-表皮交界处有坏死的角质形成细胞。皮肤形式通常在6至12个月内消失,但粘膜病变具有更慢性的演变,并可能具有恶性潜能。病因尚不清楚,可能与免疫紊乱有关。局部或全身皮质类固醇、类视黄醇和PUVA治疗是主要治疗方法,但口服皮质类固醇治疗仍需评估。
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Lichen plan et dermatoses lichénoïdes

Lichen planus is a chronic itching dermatosis of the adult, characterized by shiny flat violaceous polygonal papules. It may affect any part of the body surface, but it is most likely to appear on the extension part of the limbs. Mucous-membrane lesions are very common. Atypical forms are usual. Histological features are a superficial band-like infiltrate of lymphocytes in the superficial dermis with necrotic keratinocytes at the dermo-epidermal junction. Cutaneous forms usually disappear within 6 to 12 months, but mucous membrane lesions have a more chronic evolution, and can have a malignant potential. The aetiology remains unknown, immunological disorders are probably involved. Local or systemic corticosteroids, retinoids and PUVA therapy are the main treatments, but oral corticotherapy still need to be evaluated.

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