流动注射化学发光法测定制剂中吩噻嗪类药物

Laboratory Automation & Information Management Pub Date : 1999-11-01 DOI:10.1016/S1381-141X(99)00017-9

Tomás Pérez-Ruiz , Carmen Martı́nez-Lozano , Antonio Sanz , M.Teresa San Miguel

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引用次数: 11

摘要

提出了一种用于化学发光（CL）测定氯丙嗪、三甲吡嗪和三氟拉嗪的流动注射配置。该程序基于高氯酸铁（III）对药物的氧化作用。在不添加氧化剂的情况下，通过其对CL-鲁米诺反应的催化作用来测量所形成的Fe（II）。三种药物的线性校准图均在2.0×10−6和1.0×10−4M之间。通过研究潜在干扰的影响和分析商业药物制剂，证明了该方法对测定这些吩噻嗪的适用性。

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Flow-injection chemiluminescent determination of phenothiazines in pharmaceutical preparations

A flow-injection configuration for the chemiluminescent (CL) determination of chlorpromazine, trimeprazine and trifluoperazine is proposed. The procedure is based on the oxidation of the drugs by Fe(III) perchlorate. The Fe(II) formed is measured by its catalytic effect on the CL luminol reaction in the absence of added oxidant. Linear calibration graphs were obtained between 2.0×10⁻⁶ and 1.0×10⁻⁴ M for all three drugs. The applicability of the method to the determination of these phenothiazines was demonstrated by investigating the effect of potential interferences and by analysing commercial pharmaceutical preparations.

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