非上皮性盐皮质激素受体激活是肾脏疾病的决定因素

IF 19.3 2区 医学 Q1 UROLOGY & NEPHROLOGY Kidney International Supplements Pub Date : 2022-04-01 DOI:10.1016/j.kisu.2021.11.004
Toshifumi Nakamura , Sophie Girerd , Frederic Jaisser , Jonatan Barrera-Chimal
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引用次数: 11

摘要

慢性肾脏疾病是一个重大的全球健康挑战,盐皮质激素受体(MR)信号被认为在疾病进展中发挥作用。MR的经典作用是通过差异基因表达调节液体和电解质稳态,最近它在调节炎症和纤维化中的作用已被确定。除了在肾上皮细胞中表达MR外,还在非上皮细胞中发现,如内皮细胞、血管平滑肌细胞、足细胞和成纤维细胞。靶向这些细胞中的MR可能在提供针对肾脏和心血管系统的炎症和纤维化的保护方面发挥作用。本文介绍了来自临床前细胞特异性MR敲除小鼠模型和体外研究的数据,这些数据有助于揭示MR在非上皮细胞中的作用。这篇综述还讨论了几个潜在的靶点,这些靶点为MR信号在非上皮细胞中的靶向提供了机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Nonepithelial mineralocorticoid receptor activation as a determinant of kidney disease

Chronic kidney disease is a major global health challenge, and mineralocorticoid receptor (MR) signaling is thought to play a role in disease progression. The classic role of the MR is the regulation of fluid and electrolyte homeostasis via differential gene expression, and recently its role in modulating inflammation and fibrosis has been identified. In addition to expression of the MR in renal epithelial cells, it is also found in nonepithelial cells, such as endothelial cells, vascular smooth muscle cells, podocytes, and fibroblasts. Targeting the MR in these cells may play a role in offering protection against inflammation and fibrosis in the kidneys and the cardiovascular system. Herein, data from preclinical cell-specific MR knockout mouse models and in vitro studies that help uncover the role of the MR in nonepithelial cells are presented. This review also discusses several potential targets that offer opportunities for the targeting of MR signaling in nonepithelial cells.

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来源期刊
Kidney International Supplements
Kidney International Supplements UROLOGY & NEPHROLOGY-
CiteScore
11.80
自引率
0.00%
发文量
13
期刊介绍: Kidney International Supplements is published on behalf of the International Society of Nephrology (ISN) and comes complimentary as part of a subscription to Kidney International. Kidney International Supplements is a peer-reviewed journal whose focus is sponsored, topical content of interest to the nephrology community.
期刊最新文献
Editorial Board Table of Contents Variations in kidney care management and access: regional assessments of the 2023 International Society of Nephrology Global Kidney Health Atlas (ISN-GKHA) Update on variability in organization and structures of kidney care across world regions Capacity for the management of kidney failure in the International Society of Nephrology Newly Independent States and Russia region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA)
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