长方案卵胞浆内单精子注射的临床效果

D. Arun
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In the study group, we achieved 72% grade 1 embryo (36) and 2 weeks after embryo transfer the biochemical testing for pregnancy showed positive pregnancy in 52% (26). The average stimulation phase length was 13.5 days, (SD 5.5). The incidence of severe OHSS needing hospitalization and treatment was 2% (1/50). 8 patients observed to have evidence of mild OHSS. OHSS was observed in patients with a shorter period of stimulation phase, mean SPL among OHSS patient was 11.38 ( SD -1.6). However, it was not statistically significant ( p–0.507). The stimulation phase length did not correlate with the quality of oocyte nor the pregnancy rate as hypothesized theoretically. 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引用次数: 0

摘要

主要目的:研究采用长方案的卵胞浆内单精子注射(ICSI)的结果。分析平均刺激天数、卵巢过度刺激综合征(OHSS)发生率、取卵数量和质量。次要目的:结果与刺激期长度的相关性方法:回顾性研究2014年12月至2015年12月在我们的ART单元使用长方案进行体外受精(IVF)的50例患者。收集所有临床观察资料,包括患者详细情况、刺激天数、取卵数、OHSS发生情况。对所有临床资料进行统计学分析。结果:采用长方案进行ICSI的临床效果满意。在研究组中,我们获得了72%的1级胚胎(36例),胚胎移植2周后妊娠生化检测显示52%(26例)妊娠阳性。平均刺激阶段长度为13.5天(SD 5.5)。重度OHSS需要住院治疗的发生率为2%(1/50)。8例患者有轻度OHSS症状。OHSS患者刺激期较短,平均SPL为11.38 (SD -1.6)。但差异无统计学意义(p-0.507)。刺激期长度与卵母细胞质量和受孕率没有理论假设的相关性。结论:本研究采用长方案,临床效果满意,刺激相长度未对临床结果产生明显不良影响(1级胚胎72%,妊娠52%),未增加严重OHSS等并发症。
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Clinical Outcome of Intracytoplasmic Sperm Injection using Long Protocol
Primary aim: To study the outcome of intracytoplasmic sperm injection (ICSI) using long protocol. Analysis of the average number of days of stimulation, the incidence of ovarian hyperstimulation syndrome (OHSS), and the number and quality of oocyte retrieved. Secondary aim: Correlation of the outcome against the stimulation phase length Method: Retrospective study of 50 patients who underwent in vitro fertilisation (IVF) using the long protocol in our ART unit during December 2014 to December 2015. All clinical observations including the patient details, number of days of stimulation, the number of oocytes retrieved, the occurrence of OHSS were collected and tabulated. All clinical data were statistically analyzed. Result: The clinical outcome of ICSI using long protocol was satisfactory. In the study group, we achieved 72% grade 1 embryo (36) and 2 weeks after embryo transfer the biochemical testing for pregnancy showed positive pregnancy in 52% (26). The average stimulation phase length was 13.5 days, (SD 5.5). The incidence of severe OHSS needing hospitalization and treatment was 2% (1/50). 8 patients observed to have evidence of mild OHSS. OHSS was observed in patients with a shorter period of stimulation phase, mean SPL among OHSS patient was 11.38 ( SD -1.6). However, it was not statistically significant ( p–0.507). The stimulation phase length did not correlate with the quality of oocyte nor the pregnancy rate as hypothesized theoretically. Conclusion: The present study shows satisfactory clinical outcome using long protocol,the stimulation phase length did not show significant ill effects in the clinical outcome (72% grade 1 embryo, 52% pregnancy), nor increase complications like severe OHSS.
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