Sarilumab在2019年严重冠状病毒病肺炎中的应用

IF 0.2 Q4 RESPIRATORY SYSTEM Egyptian Journal of Chest Diseases and Tuberculosis Pub Date : 2023-04-01 DOI:10.4103/ecdt.ecdt_77_22
Ahmed El Fattah Amer, Doaa Mousa
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引用次数: 0

摘要

白细胞介素-6 (IL-6)信号阻断剂在2019冠状病毒病(COVID-19)的治疗和预防炎症进展中发挥重要作用。许多研究评估了Sarilumab治疗重症COVID-19肺炎的疗效。目的评价沙利单抗治疗重症COVID-19肺炎的疗效。患者与方法:40例严重急性呼吸综合征冠状病毒2型重症肺炎患者静脉注射沙利单抗400mg。结果患者住院时间平均为18.17±8.75 d。18例(45%)使用高流量氧气和非呼吸面罩的患者和22例(55%)使用机械通气的患者接受了sarilumab。IL-6治疗前平均为62.50±23.01,治疗后平均为31.35±33.30。13例(32.5%)患者好转,27例(67.5%)患者死亡。本研究未发现沙伐单抗严重不良反应。出院时患者血氧饱和度平均值为95.75±0.97%。入组患者血清IL-6水平基线均值与随访均值比较差异有统计学意义,分别为62.50±23.01、31.35±33.30 ng/ml, P值为0.001。结论沙律单抗可提高COVID-19重症肺炎患者IL-6水平,无严重不良反应。重症COVID-19病例的死亡率增加,因此在中度病例中早期使用沙伐单抗可能会减少疾病进展并降低死亡率。
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Sarilumab use in severe Coronavirus Disease 2019 pneumonia
Background Interleukin-6 (IL-6) signal blockers have an important role in the management of Coronavirus Disease 2019 (COVID-19) and prevent progression of inflammation. Many studies have evaluated the efficacy of Sarilumab in severe COVID-19 pneumonia. Aim Evaluation of sarilumab efficacy in severe COVID-19 pneumonia. Patients and methods In all, 40 patients with severe acute respiratory syndrome coronavirus 2 severe pneumonia received intravenous sarilumab 400 mg. Results Patients were admitted to the ICU with a mean duration of 18.17 ± 8.75 days. Eighteen (45%) patients on high-flow oxygen with nonrebreather masks and 22 (55%) patients on mechanical ventilation received sarilumab. IL-6 level is with a mean of 62.50 ± 23.01 before sarilumab and a mean of 31.35 ± 33.30 after sarilumab. Thirteen (32.5%) patients improved and 27 (67.5%) patients died. No sarilumab serious adverse effects were detected in this study. Patient oxygen saturation on discharge mean was 95.75±.97%. Concerning serum IL-6 levels among the recruited patients, there was statistically significant difference between the mean baseline level compared with the follow-up levels, 62.50 ± 23.01 and 31.35 ± 33.30 ng/ml, respectively, with a P value of 0.001. Conclusion Sarilumab improves IL-6 level in COVID-19 patients with severe pneumonia with no serious adverse effects. Mortality rate increased in severe COVID-19 cases, so early use of sarilumab in moderate cases may decrease disease progression and decrease mortality rate.
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来源期刊
自引率
0.00%
发文量
46
审稿时长
22 weeks
期刊介绍: The journal will cover technical and clinical studies related to health, ethical and social issues in field of The Egyptian Journal of Chest Diseases and Tuberculosis aims to publish and inform readers and all chest physicians of the progress in medical research concerning all aspect of chest diseases. Publications include original articles review articles, editorials, case studies and reports which are relevant to chest diseases. The Journal also aims to highlight recent updates in chest medicine. . Articles with clinical interest and implications will be given preference.
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