T. Toyama, H. Hoshizaki, S. Kasama, Yusuke Miyaishi, Hakuken Kan, E. Yamashita, R. Kawaguchi, S. Oshima, M. Kurabayashi
{"title":"超早期粒细胞集落刺激因子治疗急性心肌梗死的有效性","authors":"T. Toyama, H. Hoshizaki, S. Kasama, Yusuke Miyaishi, Hakuken Kan, E. Yamashita, R. Kawaguchi, S. Oshima, M. Kurabayashi","doi":"10.17996/anc.19-00099","DOIUrl":null,"url":null,"abstract":"Objective: It has been reported that granulocyte-colony-stimulating-factor (G-CSF) induces myocardial regeneration and revascularization after acute myocardial infarction (AMI) by mobilizing bone marrow stem cells and suppressing apoptosis of endothelial cells in the injured heart. This study investigated whether hyper early G-CSF therapy was beneficial for AMI patients. Methods: Forty consecutive patients with initial ST-segment elevation AMI were randomized to receive intravenous infusion of G-CSF at 2μg/kg over 30 min (G-CSF group) or infusion of normal saline (control group) once daily for 5 days. The first dose was administered during primary percutaneous coronary intervention just after hospitalization. In the subacute period and 6 months after AMI, all patients underwent myocardial scintigraphy, including 99m Tc-sestamibi imaging of myocardial perfusion and 123 I-beta-methyl-piodophenylpentadecanoic-acid ( 123 I-BMIPP) imaging to assess fatty acid metabolism. Results: The two groups had a similar myocardial area at risk, as evaluated by the extent score on subacute 123 IBMIPP imaging. Compared with the control group, the G-CSF group had a significantly smaller (p<0.05) total defect score on 99m Tc-sestamibi and 123 I-BMIPP imaging at 6 months. In addition, the left ventricular ejection fraction and regional wall motion score were larger in the G-CSF group than in the control group during the subacute period and after 6 months. Conclusions: Hyper early G-CSF therapy improves myocardial perfusion, fatty acid metabolism, and cardiac function after AMI.","PeriodicalId":72228,"journal":{"name":"Annals of nuclear cardiology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Usefulness of Hyper Early Granulocyte-colony-stimulating Factor Therapy for Patients with Acute Myocardial Infarction\",\"authors\":\"T. Toyama, H. Hoshizaki, S. Kasama, Yusuke Miyaishi, Hakuken Kan, E. Yamashita, R. Kawaguchi, S. Oshima, M. Kurabayashi\",\"doi\":\"10.17996/anc.19-00099\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: It has been reported that granulocyte-colony-stimulating-factor (G-CSF) induces myocardial regeneration and revascularization after acute myocardial infarction (AMI) by mobilizing bone marrow stem cells and suppressing apoptosis of endothelial cells in the injured heart. This study investigated whether hyper early G-CSF therapy was beneficial for AMI patients. Methods: Forty consecutive patients with initial ST-segment elevation AMI were randomized to receive intravenous infusion of G-CSF at 2μg/kg over 30 min (G-CSF group) or infusion of normal saline (control group) once daily for 5 days. The first dose was administered during primary percutaneous coronary intervention just after hospitalization. In the subacute period and 6 months after AMI, all patients underwent myocardial scintigraphy, including 99m Tc-sestamibi imaging of myocardial perfusion and 123 I-beta-methyl-piodophenylpentadecanoic-acid ( 123 I-BMIPP) imaging to assess fatty acid metabolism. Results: The two groups had a similar myocardial area at risk, as evaluated by the extent score on subacute 123 IBMIPP imaging. Compared with the control group, the G-CSF group had a significantly smaller (p<0.05) total defect score on 99m Tc-sestamibi and 123 I-BMIPP imaging at 6 months. In addition, the left ventricular ejection fraction and regional wall motion score were larger in the G-CSF group than in the control group during the subacute period and after 6 months. Conclusions: Hyper early G-CSF therapy improves myocardial perfusion, fatty acid metabolism, and cardiac function after AMI.\",\"PeriodicalId\":72228,\"journal\":{\"name\":\"Annals of nuclear cardiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of nuclear cardiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17996/anc.19-00099\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of nuclear cardiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17996/anc.19-00099","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
目的:有报道称,粒细胞集落刺激因子(G-CSF)通过动员骨髓干细胞和抑制心肌内皮细胞凋亡诱导急性心肌梗死(AMI)后心肌再生和血运重建。本研究探讨了早期高G-CSF治疗是否对AMI患者有益。方法:连续40例st段抬高型AMI患者,随机分为两组,分别静脉滴注G-CSF 2μg/kg / 30 min (G-CSF组)和生理盐水(对照组),每日1次,连用5 d。第一次剂量是在住院后的初级经皮冠状动脉介入治疗期间给予的。在亚急性期和AMI后6个月,所有患者均行心肌显像,包括99m Tc-sestamibi心肌灌注显像和123 i - β -甲基-聚苯五酸(123 I-BMIPP)显像评估脂肪酸代谢。结果:通过亚急性123 IBMIPP成像程度评分评估,两组有相似的心肌危险面积。与对照组相比,G-CSF组在6个月时99m Tc-sestamibi和123 I-BMIPP成像的总缺损评分明显低于对照组(p<0.05)。此外,在亚急性期和6个月后,G-CSF组左室射血分数和局部壁运动评分均高于对照组。结论:早期高G-CSF治疗可改善AMI后心肌灌注、脂肪酸代谢和心功能。
Usefulness of Hyper Early Granulocyte-colony-stimulating Factor Therapy for Patients with Acute Myocardial Infarction
Objective: It has been reported that granulocyte-colony-stimulating-factor (G-CSF) induces myocardial regeneration and revascularization after acute myocardial infarction (AMI) by mobilizing bone marrow stem cells and suppressing apoptosis of endothelial cells in the injured heart. This study investigated whether hyper early G-CSF therapy was beneficial for AMI patients. Methods: Forty consecutive patients with initial ST-segment elevation AMI were randomized to receive intravenous infusion of G-CSF at 2μg/kg over 30 min (G-CSF group) or infusion of normal saline (control group) once daily for 5 days. The first dose was administered during primary percutaneous coronary intervention just after hospitalization. In the subacute period and 6 months after AMI, all patients underwent myocardial scintigraphy, including 99m Tc-sestamibi imaging of myocardial perfusion and 123 I-beta-methyl-piodophenylpentadecanoic-acid ( 123 I-BMIPP) imaging to assess fatty acid metabolism. Results: The two groups had a similar myocardial area at risk, as evaluated by the extent score on subacute 123 IBMIPP imaging. Compared with the control group, the G-CSF group had a significantly smaller (p<0.05) total defect score on 99m Tc-sestamibi and 123 I-BMIPP imaging at 6 months. In addition, the left ventricular ejection fraction and regional wall motion score were larger in the G-CSF group than in the control group during the subacute period and after 6 months. Conclusions: Hyper early G-CSF therapy improves myocardial perfusion, fatty acid metabolism, and cardiac function after AMI.