{"title":"一种检测生物活性所必需的共同特征的方法:醛糖还原酶抑制剂的应用","authors":"Tamio Yasukawa ∗ , Katsunori Satoh , Noriaki Gotoh , Toshimasa Ishida ∗ , Shiegeuki Sumiya , Kunihiro Kitamura ∗","doi":"10.1016/0898-5529(90)90116-P","DOIUrl":null,"url":null,"abstract":"<div><p>A computer system for rational molecular design is described. The system, named as ANALOGS, provides the triangular elements consisting of functional atoms for the comparison of a number of stereochemically different compounds. Application of the system for aldose reductase inhibitors is described. The results obtained give some interesting information on the inhibitor-binding site of aldose reductase and on the structural features of the inhibitors.</p></div>","PeriodicalId":101214,"journal":{"name":"Tetrahedron Computer Methodology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0898-5529(90)90116-P","citationCount":"1","resultStr":"{\"title\":\"A method to detect common features necessary for biological activity: Application of ANALOGS for aldose reductase inhibitors\",\"authors\":\"Tamio Yasukawa ∗ , Katsunori Satoh , Noriaki Gotoh , Toshimasa Ishida ∗ , Shiegeuki Sumiya , Kunihiro Kitamura ∗\",\"doi\":\"10.1016/0898-5529(90)90116-P\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A computer system for rational molecular design is described. The system, named as ANALOGS, provides the triangular elements consisting of functional atoms for the comparison of a number of stereochemically different compounds. Application of the system for aldose reductase inhibitors is described. The results obtained give some interesting information on the inhibitor-binding site of aldose reductase and on the structural features of the inhibitors.</p></div>\",\"PeriodicalId\":101214,\"journal\":{\"name\":\"Tetrahedron Computer Methodology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1990-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0898-5529(90)90116-P\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tetrahedron Computer Methodology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/089855299090116P\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron Computer Methodology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/089855299090116P","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A method to detect common features necessary for biological activity: Application of ANALOGS for aldose reductase inhibitors
A computer system for rational molecular design is described. The system, named as ANALOGS, provides the triangular elements consisting of functional atoms for the comparison of a number of stereochemically different compounds. Application of the system for aldose reductase inhibitors is described. The results obtained give some interesting information on the inhibitor-binding site of aldose reductase and on the structural features of the inhibitors.
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