电纺丝聚己内酯/羟基磷灰石复合材料在伤口敷料中的应用

Ali Hasan Mohsan, N. Ali
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引用次数: 0

摘要

聚己内酯聚合物具有良好的生物相容性,在医学上有着广泛的应用。采用静电纺丝法制备了浓度为0.05 ~ 0.4%的羟基磷灰石(HA)聚ε-内酯(PCL)纳米复合纤维毡。利用红外光谱(FTIR)和场发射扫描电镜(FESEM)对制备的生物复合纤维的化学性能进行了评价,并对纳米纤维的孔隙率、接触角以及力学性能(杨氏模量和抗拉强度)进行了研究。FTIR结果表明,纯PCL纤维和PCL/HA纳米纤维都出现了所有的键。FESEM纳米纤维显示,在(0.05%和1%wt.)的HA值下,纤维直径从54.13 nm增加到155.79 nm。(PCL/HA)复合材料的孔隙率、润湿性均有所改善,纤维支架的接触角从103.59°降低到85.57°。羟基磷灰石的掺入提高了纳米纤维支架的抗拉强度,0.4%的掺入最大抗拉强度约为0.127 MPa,伸长率降至40%。
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Electro spinning of Polycaprolactone / Hydroxyapatite Composites in Wound Dressing Application
Polycaprolactone polymer is widely used in medical applications due to its biocompatibility. Electro spinning was used to create poly (ε- caprolactone) (PCL) nanocomposite fiber mats containing hydroxyapatite (HA) at concentrations ranging from 0.05 to 0.4% wt. The chemical properties of the fabricated bio composite fibers were evaluated using FTIR and morphologically using field-emission scanning-electron microscopy (FESEM), Porosity, contact angle, as well as mechanical testing(Young Modulus and Tensile strength) of the nanofibers were also studied. The FTIR results showed that all the bonds appeared for the pure PCL fiber and the PCL/HA nano fibers. The FESEM nano fiber showed that the fiber diameter increased from 54.13 to 155.79 (nm) at the HA values from (0.05 % and 1%wt.). Porosity, wettability of (PCL/HA) composites has improved, and the contact angle has decreased from 103.59o to 85.57o for fibrous scaffolds. The inclusion of hydroxyapatite increased the tensile strength of nano fiber scaffolds, and the maximum tensile strength of 0.4% percent was about 0.127 MPa, with a lowering in elongation to 40%.
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