新型嘧啶的合成、表征及抗炎活性研究

P. Priyadarsini, V. Rao, C. Rao
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引用次数: 0

摘要

以2-羟基苯乙酮和肉桂酸为原料,以1,3-二酮为中间体缩合合成了一些嘧啶衍生物。在计算量的微量三乙胺和吡啶存在下,与尿素、硫脲和胍反应生成取代嘧啶。对合成的化合物进行了物理性质、核磁共振、质谱等表征,并对其抗炎活性进行了筛选。
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Synthesis, Characterization and Anti-inflammatory Activity of New Pyrimidines
The synthesis of some pyrimidine derivatives was achieved by conden-sation of 2-hydroxyacetophenone and cinnamic acid as starting materials through 1,3-diketones as intermediates. The resulting diketones have been converted into substituted pyrimidines by reaction with urea, thiourea and guanidine in the presence of trace of triethylamine and pyridine in calculated quantity. The synthesized compounds were characterized by their physical properties, NMR and LC-mass spectroscopic studies and also screened for their anti-inflammatory activity.
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