临时制备药物混悬液稳定性研究综述

S. Naveed, F. Akhtar, S. Khan
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引用次数: 1

摘要

目的:对即食制剂的稳定性研究进行综述。材料和方法:根据制剂的性质,检查稳定性研究使用不同的方法,如目视检查、pH检查、不同温度储存和HPLC。结果:药物混悬液的稳定性问题包括物理性质和化学性质的变化。因此,最重要的是配方师必须确保配方在整个保质期内的功效。本文所采用的稳定性检查方法是有效的,达到了标准,因此患者可以根据推荐的时间使用这些临时制剂。结论:我们的应力研究可以得出结论,这些悬浮液不能长时间储存(平均90-120天);但它们在120天以下是稳定的(取决于制剂),所以我们可以使用这些制剂,因为如果在推荐的时间内使用,没有稳定性问题,不可否认,临时制备的混悬液可以帮助儿童,老年人和无意识的患者给药。
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An Overview on Stability of Extemporaneously Prepared Pharmaceutical Suspension
Aim: The aim of this study was to write review on stability studies of extemporaneous preparations. Materials and methods: Different methods are used for checking stability studies, depending on the nature of the preparations, like visual inspection, pH checking, different temperature storage, and HPLC. Results: It was found that the stability concern with the pharmaceutical suspensions includes the variation in both physical and chemical properties. Therefore, it is most important that formulator must ensure the efficacy of the formulation throughout the shelf life period. In this review article, method used for stability checking is valid and up to mark, so patient can use these extemporaneous preparations according to recommended period of time. Conclusion: We can conclude of our Stress studies that these suspensions cannot be stored over long period of time (average 90-120 days); but they are stable below 120 days (depending on the preparation) so we can have used these preparations because there is no stability issue if used in within recommended time-period, undeniably extemporaneously prepared suspensions can be a helpful for pediatric, geriatric and unconscious patients in drug dosing.
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