1,2-氨基醇、硼氢化钠和二碘甲烷原位制备恶唑硼烷催化剂的新方法用于前手性酮和n -取代亚胺的不对称还原

The Open Catalysis Journal Pub Date : 2009-06-16 DOI:10.2174/1876214X00902010096

Kettouche Hichem Sadrik, Djerourou Abdel Hafid

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引用次数: 3

摘要

以硼氢化钠/CH2I2试剂体系生成的1,2-氨基醇和硼烷为原料，在室温下原位制备了恶唑硼烷催化剂。用这种方法制备的恶唑硼烷/BH3试剂体系可用于将前手性酮和n -取代亚胺还原为相应的醇和胺，具有中等至良好的对映体过量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A New Method for the Preparation of Oxazaborolidine Catalyst In Situ Using 1,2-Aminoalcohol, Sodium Borohydride, and Diiodomethane for the Asymmetric Reduction of Prochiral Ketones and N-Substituted Imines

An oxazaborolidine catalyst is readily prepared in situ at room temperature in THF using 1,2-aminoalcohols and borane generated from sodium borohydride/CH2I2 reagent system. The oxazaborolidine/BH3 reagent system prepared in this way is useful for the reduction of prochiral ketones and N-substituted imines to the corresponding alcohols and amines with moderate to good enantiomeric excesses.

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The Open Catalysis Journal

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