M. Banwell, K. Jolliffe, David T. J. Loong, K. Mcrae, Filisaty Vounatsos
{"title":"化学酶法合成12元大环内酯(−)-枝磷脂A","authors":"M. Banwell, K. Jolliffe, David T. J. Loong, K. Mcrae, Filisaty Vounatsos","doi":"10.1039/B110018A","DOIUrl":null,"url":null,"abstract":"The enantiomerically pure cis-1,2-dihydrocatechol 7, which is obtained by microbial oxidation of chlorobenzene, has been converted, via a sequence of reactions including ring-closing metathesis and Yamaguchi lactonisation steps, into the natural product (−)-cladospolide A (1).","PeriodicalId":17267,"journal":{"name":"Journal of The Chemical Society-perkin Transactions 1","volume":"95 1","pages":"22-25"},"PeriodicalIF":0.0000,"publicationDate":"2002-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"A chemoenzymatic synthesis of the 12-membered macrolide (−)-cladospolide A\",\"authors\":\"M. Banwell, K. Jolliffe, David T. J. Loong, K. Mcrae, Filisaty Vounatsos\",\"doi\":\"10.1039/B110018A\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The enantiomerically pure cis-1,2-dihydrocatechol 7, which is obtained by microbial oxidation of chlorobenzene, has been converted, via a sequence of reactions including ring-closing metathesis and Yamaguchi lactonisation steps, into the natural product (−)-cladospolide A (1).\",\"PeriodicalId\":17267,\"journal\":{\"name\":\"Journal of The Chemical Society-perkin Transactions 1\",\"volume\":\"95 1\",\"pages\":\"22-25\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2002-12-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of The Chemical Society-perkin Transactions 1\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1039/B110018A\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of The Chemical Society-perkin Transactions 1","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1039/B110018A","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A chemoenzymatic synthesis of the 12-membered macrolide (−)-cladospolide A
The enantiomerically pure cis-1,2-dihydrocatechol 7, which is obtained by microbial oxidation of chlorobenzene, has been converted, via a sequence of reactions including ring-closing metathesis and Yamaguchi lactonisation steps, into the natural product (−)-cladospolide A (1).