反复损伤下角质层的修复动力学

E. Uhoda, C. Piérard‐franchimont, B. Debatisse, Xuemin Wang, G. Piérard
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引用次数: 20

摘要

背景:表面活性剂改变了角质层(SC)的结构和功能。增强修复机制是一些护肤配方的目标。目的:设计一种实验程序,可以区分外用产品对受损SC的修复效果。方法:对20名志愿者进行对照SC剥离,然后在表面活性剂溶液中反复浸泡前臂,以损害SC屏障功能。比较了两种试验配方。在开始SC损害之前,每天应用两次,持续2周,并在接下来的2周内持续浸泡过程。日常评估包括客观测量参数,包括经皮失水、被动可持续SC水化值和使用二羟丙酮试验的表皮周转率。结果:实验程序允许清楚地区分在局部配方之间的SC修复动力学的差异。在本研究设计中,屏障功能的修复反映了SC的更新。结论:本实验设计减缓了SC屏障功能的修复速度。因此,它增加了生物计量测量评估一些主要SC属性的灵敏度。它还可以更好地模拟长期暴露于刺激性外源性药物的受试者所经历的常见体内情况。
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Repair Kinetics of the Stratum corneum under Repeated Insults
Background: The stratum corneum (SC) structure and functions are altered by surfactants. Enhancing the repair mechanisms is a goal for some skin care formulations. Aim: To design an experimental procedure allowing the discrimination of repair efficacy for topical products applied to threatened SC. Method: Controlled SC strippings followed by repeated forearm soak sessions in surfactant solutions were used to compromise the SC barrier function in 20 volunteers. Two test formulations were compared. They were applied twice daily for 2 weeks before initiating the SC damages, and for the next 2 weeks while sustaining the procedure of soak sessions. Daily assessments involved objective measurements of parameters including transepidermal water loss, the value of the passive sustainable SC hydration and the epidermal turnover rate using the dihydroxyacetone test. Result: The experimental procedure allowed to clearly distinguish the differences in the kinetics of SC repair between the topical formulations. In the present study design, the repair of the barrier function mirrored the SC renewal. Conclusion: The present experimental design slows down the repair rate of the SC barrier function. Thus, it increases the sensitivity of biometrological measurements assessing some of the major SC properties. It also better mimics the common in vivo situation experienced by subjects chronically exposed to irritant xenobiotics.
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Acknowledgement to Referees for Exogenous Dermatology 2004 Contents Vol. 3, 2004 Author Index Vol. 3, 2004 Is There Evidence that Geraniol Causes Allergic Contact Dermatitis? Subject Index Vol. 3, 2004
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