{"title":"玩具贵宾犬以口腔为主的自身免疫性表皮下起泡病","authors":"K. Nakajima, K. Iyori, K. Nishifuji","doi":"10.2736/JJVD.22.201","DOIUrl":null,"url":null,"abstract":"A 6-year-old, female toy poodle exhibited dolorous erosion on the lip and oral lesions with halitosis. The pain on the lip improved by topical and systemic steroids as well as antibiotics prescribed by local veterinarians, whereas mucosal lesions did not improve. Histopathological analysis of buccal mucosa revealed separation of the dermo-epithelial junction. Direct immunofluorescence analysis revealed the deposition of IgG in perinuclear areas as well as just beneath the basal keratinocytes. Based on these findings, the present case was diagnosed with either mucous membrane pemphigoid (MMP) or anti-laminin 332 MMP.","PeriodicalId":22603,"journal":{"name":"The Japanese Journal of Veterinary Dermatology","volume":"18 1","pages":"201-204"},"PeriodicalIF":0.0000,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Autoimmune Subepidermal Blistering Disease with Predominant Oral Involvement in a Toy Poodle\",\"authors\":\"K. Nakajima, K. Iyori, K. Nishifuji\",\"doi\":\"10.2736/JJVD.22.201\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A 6-year-old, female toy poodle exhibited dolorous erosion on the lip and oral lesions with halitosis. The pain on the lip improved by topical and systemic steroids as well as antibiotics prescribed by local veterinarians, whereas mucosal lesions did not improve. Histopathological analysis of buccal mucosa revealed separation of the dermo-epithelial junction. Direct immunofluorescence analysis revealed the deposition of IgG in perinuclear areas as well as just beneath the basal keratinocytes. Based on these findings, the present case was diagnosed with either mucous membrane pemphigoid (MMP) or anti-laminin 332 MMP.\",\"PeriodicalId\":22603,\"journal\":{\"name\":\"The Japanese Journal of Veterinary Dermatology\",\"volume\":\"18 1\",\"pages\":\"201-204\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Japanese Journal of Veterinary Dermatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2736/JJVD.22.201\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Japanese Journal of Veterinary Dermatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2736/JJVD.22.201","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Autoimmune Subepidermal Blistering Disease with Predominant Oral Involvement in a Toy Poodle
A 6-year-old, female toy poodle exhibited dolorous erosion on the lip and oral lesions with halitosis. The pain on the lip improved by topical and systemic steroids as well as antibiotics prescribed by local veterinarians, whereas mucosal lesions did not improve. Histopathological analysis of buccal mucosa revealed separation of the dermo-epithelial junction. Direct immunofluorescence analysis revealed the deposition of IgG in perinuclear areas as well as just beneath the basal keratinocytes. Based on these findings, the present case was diagnosed with either mucous membrane pemphigoid (MMP) or anti-laminin 332 MMP.
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