COVID-19宿主基因组数据库:与COVID-19宿主遗传学相关的综合数据库

Journal of International Translational Medicine Pub Date : 2022-07-22 DOI:10.3390/ijtm2030028

Bhavya Banjan, M. Albeshr, S. Mahboob, I. Manzoor, R. Das

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引用次数: 0

摘要

当前，世界正面临2019冠状病毒病(COVID-19)大流行。已经进行了几项全基因组和外显子组研究(GWAS和EWAS)，以确定宿主遗传构成的变异性，这可能强调了COVID-19严重程度和临床表现的个体间变异性。由于现有文章的数量庞大，对于COVID-19研究人员来说，创建与COVID-19相关的宿主特异性遗传变异和基因列表既耗时又极具挑战性。为此，我们建立了新冠病毒宿主基因组数据库。这是目前唯一一个专门处理COVID-19宿主特异性遗传变异和基因的免费使用数据库。使用超文本标记语言(HTML)、层叠样式表(CSS)、超文本预处理器(PHP)和MySQL服务器(版本5.7.38)开发网站、存储和提取数据。到目前为止，从63篇先前发表的文章中收集了787种基因变异。表格数据超链接到原始文章，用户可以从数据库下载所有数据。COVID-19宿主基因组数据库每个月都在不断修订，可以使研究遗传变异的研究界受益，以改进COVID-19的治疗和预防策略。

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COVID-19 Host GenomeDB: A Comprehensive Database Related to COVID-19 Host Genetics

The world is currently faced with a pandemic of coronavirus disease 2019 (COVID-19). Several genome-wide and exome-wide studies (GWAS and EWAS) have been performed to identify the variability in the host genetic constitution that likely underlines the inter-individual variabilities in COVID-19 severity and clinical manifestation. Due to the magnitude of the articles available, creating a list of host-specific genetic variants and genes associated with COVID-19 can be both time-consuming and extremely challenging for COVID-19 researchers. To this end, the COVID-19 Host Genome database was built. This is currently the only dedicated, free-to-use database that deals solely with COVID-19 host-specific genetic variants and genes. HyperText Markup language (HTML), Cascading Style Sheets (CSS), Hypertext Preprocessor (PHP), and My Structured Query Language (MySQL) server (version 5.7.38) were used to develop the website, storage, and extraction of the data. So far, 787 genetic variants from 63 previously published articles were collected. The tabular data are hyperlinked to the original articles and the users can download all data from the database. COVID-19 Host GenomeDB is being revised constantly every month, and can benefit the research community studying the genetic variants to improve COVID-19 treatment and prevention strategies.

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来源期刊

Journal of International Translational Medicine MEDICINE, RESEARCH & EXPERIMENTAL-

自引率

0.00%

发文量

317

审稿时长

8 weeks

期刊介绍： Journal of International Translational Medicine (JITM, ISSN 2227-6394), founded in 2012, is an English academic journal published by Journal of International Translational Medicine Co., Ltd and sponsored by International Fderation of Translational Medicine. JITM is an open access journal freely serving to submit, review, publish, read and download full text and quote. JITM is a quarterly publication with the first issue published in March, 2013, and all articles published in English are compiled and edited by professional graphic designers according to the international compiling and editing standard. All members of the JITM Editorial Board are the famous international specialists in the field of translational medicine who come from twenty different countries and areas such as USA, Britain, France, Germany and so on.