口腔-牙周健康与细胞因子风暴:相关性及预防措施

Vanshika Jain, Rizwana B. Mallick
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摘要

2019冠状病毒病(COVID-19)席卷全球,影响所有年龄组,并呈现出大量体征和症状。细胞因子风暴显示出高死亡率,被确定为受影响个体死亡的最常见罪魁祸首之一。在以插管和重症监护病房(ICU)入院形式出现严重并发症的患者中,细胞因子水平升高再次被确定为一个重要因素,表明它们在疾病结局中起着重要作用。牙周炎被认为是一种无声的大流行,是个体中最常见的口腔疾病。斑块和结石的增加是主要的诱因,刺激牙周组织中的炎症细胞,导致细胞因子的释放。使用可移动或固定义齿的个体感染真菌的风险增加,真菌感染也被认为会增加细胞因子水平,并使感染COVID-19的个体病情恶化。本综述的重点是口腔卫生措施和经过科学验证的辅助工具,这些措施和辅助工具可用于患者在家中降低口腔细胞因子水平和COVID-19相关并发症的风险,从而在不鼓励选择性牙科手术和患者缺乏专业牙科干预的情况下使其变得敏感。机械清除斑块和结石不能用辅助工具代替,但重要的是要采取辅助措施,以提高卫生效率。牙刷也应该保持卫生,以防止疾病的发展和传播。不仅健康人或感染者需要遵守这些建议,而且病毒感染康复的患者也需要遵守这些建议,以避免可能发生黑木耳感染的风险。
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Oral-Periodontal Health and Cytokine Storm: Correlation and Preventive Measures
Coronavirus disease 19 (COVID-19) has taken the world by storm, affecting all age groups alike and presenting a plethora of signs and symptoms. Showcasing a high mortality rate, cytokine storm is identified as one of the most common culprits for death in affected individuals. In patients undergoing severe complications in the form of intubations and intensive care unit (ICU) admissions, increased cytokine levels have again been identified as a significant factor, indicating their substantial role in disease outcomes. Periodontitis, which is identified as a silent pandemic, is the most common oral disease that is found in individuals. The increased accumulations of plaques and calculus are the main causative agents, stimulating inflammatory cells in the periodontal tissue, leading to cytokine release. Individuals with the removable or fixed dental prosthesis are at increased risk of contracting fungal infections, which are also identified as increasing the cytokine levels and worsening an individual’s condition contracted with COVID-19. This review focuses on oral hygiene measures and scientifically proven aids that can be used by patients at home for reducing oral cytokine levels and the risk of COVID-19 related complications, thereby sensitizing them at a time when elective dental procedures are discouraged and patients are devoid of professional dental intervention. Mechanical removal of plaques and calculus cannot be substituted with auxiliary aids, but it is important that adjunct practices be adopted for efficient hygiene. Toothbrush hygiene should also be practiced to prevent disease progression and transmission. Adherence to these recommendations is not only required for healthy or infected individuals but also for viral infection recovered patients to avoid the possible risk of developing the black fungus infection.
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