G. Bormans , A. Janssen , P. Adriaens , D. Crombez , A. Witsenboer , J. de Goeij , L. Mortelmans , A. Verbruggen
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A 62Zn/62Cu generator for the routine production of 62Cu-PTSM
We have developed an improved 62Cu-generator system based on a small (25 mm × 5 mm) ion exchange column which allows the instant production of 62Cu-PTSM ready for injection.
The generator column can rapidly be eluted with a high yield in a volume of 1 mL to afford an eluate with largely acceptable radionuclidic purity. Collection of the eluate in a labelling kit which contains the PTSM ligand in an appropriate buffer allows to obtain in less than 30 s a highly pure 62Cu-PTSM preparation that can be injected intravenously.
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