减少学龄儿童疟疾发病率的全球卫生倡议

A. Macnab
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引用次数: 0

摘要

背景:审查减少疟疾对学龄儿童造成的疾病负担的全球举措。重点放在有可能降低死亡率和发病率、改善儿童的健康和上学能力、避免疟疾影响其潜在学业成绩和尽量减少短期和长期认知障碍风险的办法上。方法:使用与疟疾和教育相关的定义术语进行文献检索,并对选定的关键文献进行范围审查,以提供所确定的挑战和潜在解决方案的叙述性总结。结果:有强有力的证据表明,学龄儿童特别容易感染疟疾,需要采取特殊措施加以保护;鉴于目前与疟疾相关的发病率和死亡率水平,人们普遍呼吁采用更好的诊断方法和方案创新。广泛教育儿童因果关系、预防和所需护理的学校规划可以改善及时诊断和治疗的可及性;然而,目前国家疟疾控制干预措施并未专门针对学龄儿童。文献描述了干预策略,包括季节性化学预防、间歇性保护性治疗和与被忽视的热带病的大规模药物管理相关的抗疟疾治疗。最近,基于世卫组织认可的诊断和治疗原则的社区参与性干预模式教会教师使用快速即时诊断检测对在校所有患病儿童进行筛查,并及时使用青蒿素联合疗法进行治疗;发病率和缺勤率大大降低。对最优干预策略尚无共识;方法需要有所不同,但是存在“什么有效以及为什么有效”的证据,可以指导每个流行地区采取建设性的实施措施。结论:疟疾证明了卫生不平等如何对儿童的健康和从教育中受益的能力产生负面影响,但存在简单有效的基于学校的方法,可以对发病率产生积极影响,提供获得世卫组织认可的诊断和治疗的机会,适用于全球,并可以提高儿童的学习能力。关键词:旷工;青蒿素联合治疗;认知障碍;间歇保护性治疗;快速诊断检测;季节性疟疾化学预防;收稿日期:2020年5月14日评审日期:2020年6月14日修订日期:2020年6月28日接收日期:2020年6月28日doi: 10.35898/ghmj-41578
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Global Health Initiatives to Reduce Malaria Morbidity in School-aged Children
Background: To review global initiatives to reduce the burden of disease from malaria on school-aged children. The focus is on approaches with potential to reduce mortality and morbidity, improve the health and ability of children to attend school, avoid malaria impacting their potential academic achievement, and minimize the risk of short- and long-term cognitive impairment. Methods: Literature searches using defined terms related to malaria and education, and a scoping review of the key literature selected, to provide a narrative summary of the challenges and potential solutions identified. Results: There is robust evidence that school-aged children are particularly vulnerable to malaria, and need special measures to protect them; calls are widespread for better diagnostic approaches and program innovation because of current levels of malaria-related morbidity and mortality. School-based programs that educate children broadly on causation, prevention and care required can improve access to timely diagnosis and treatment; however, currently national malaria control interventions do not specifically target school-age children. The literature describes intervention strategies that include seasonal chemoprophylaxis, intermittent protective treatment and antimalarial therapy linked to mass drug administration for neglected tropical diseases. Recently, a community participatory intervention model based on WHO-endorsed diagnostic and treatment principles has taught teachers to screen all children sick at school using rapid point-of-care diagnostic testing and treat promptly with Artemesinin combination therapy; morbidity and absenteeism are significantly reduced. There is no consensus on the optimal intervention strategy; approaches will need to vary, but evidence of ‘what works and why’ exists to guide constructive implementation measures in each endemic region. Conclusion: Malaria exemplifies how health inequity negatively impacts a child’s health and ability to benefit from education, yet simple and effective school-based approaches exist that positively impact morbidity, provide access to WHO-endorsed diagnosis and treatment, are applicable worldwide and can increase the capacity of children to learn. Keywords: Absenteeism; Artemesinin Combination Therapy; Cognitive Impairment; Intermitient Protective Treatment; Rapid Diagnostic Testing; Seasonal Malaria Chemoprophylaxis; Teachers Received: 14 May 2020 Reviewed: 14 June 2020 Revised: 28 June 2020 Accepted: 28 June 2020 DOI: 10.35898/ghmj-41578  
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