瓜石榴叶提取物对链脲佐菌素诱导Wistar小鼠心脏保护作用的分子硅分析

R. Manikandan, B. Balamuralikrishnan, Arthi Boro, P. Karthika, M. Arun, S. Velayuthaprabhu, Arunkumar Malaisamy, Rengasamy Lakshminarayanan Rengarajan, A. Vijaya Anand
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引用次数: 2

摘要

心血管疾病及其并发症已被认为是发病率和死亡率的主要原因。目前市场上的药物治疗心血管疾病是有效的,但有许多不良反应。目前,草药产品因其副作用小而受到研究人员的关注。本研究探讨番石榴叶乙醇提取物对心脏的保护作用。(P. guajava)在链脲佐菌素(STZ)处理的动物模型中进行了评价。研究中获得的小鼠被分为五组,每组由六只小鼠组成。用番石榴叶乙醇提取物(300 mg/kg体重[b.w.])治疗中毒小鼠。结果与标准药物(格列苯脲)处理小鼠(3 mg/kg b.w)进行比较。进一步研究考虑以下参数:肌酸激酶-肌脑(CK- mb),肌酸激酶(CK),肌钙蛋白,溶酶体和线粒体酶。对接研究完成。毒素诱导小鼠心肌标志物酶和溶酶体酶水平显著升高,线粒体酶水平显著降低。瓜石榴叶乙醇提取物处理后,各指标水平均显著逆转至正常范围(P < 0.05)。此外,在对接分析中,α -松油醇、环戊anecarboxamide、愈木酚(倍半萜类醇)、1h -环丙炔、四环三烷-9-醇、休眠/脱落酸和表绿酚等化合物与相应蛋白质分子的相互作用证明了瓜石榴叶具有保护心脏的作用。由此可见,番石榴叶乙醇提取物具有一定的心脏保护作用。
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Impact on cardioprotective effect of Psidium guajava leaves extract in streptozotocin-induced Wistar mice with molecular in silico analysis
Cardiovascular disease (CVD) and its complications have been regarded as the leading cause of morbidity and mortality. The drugs available in the market are effective to treat CVD, but with many adverse reactions. Nowadays, herbal products are the attention of researchers because of their less adverse effects. In this study, the cardioprotective effects of ethanolic leaves extract of Psidium guajava Linn. (Guava) (P. guajava) were evaluated in streptozotocin (STZ)-treated animal models. Mice acquired for the study were divided into five groups, each consisting of six mice. The toxin-induced mice were treated with the ethanolic leaves extract of P. guajava (300 mg/kg body weight [b.w.]). The results were compared to the standard drug (glibenclamide)-treated mice (3 mg/kg b.w.). The following parameters were considered for further investigations: creatine kinase-muscle brain (CK-MB), creatine kinase (CK), troponin, lysosomal, and mitochondrial enzymes. Then the docking study was accomplished. The levels of cardiac marker enzymes and lysosomal enzymes increased significantly in the toxin-induced mice, while the level of mitochondrial enzyme decreased significantly. During treatment with the ethanolic leaves extract of P. guajava, the levels of all parameters were notably reversed to normal range (P < 0.05). Further, in docking analysis, the interaction of compounds, such as alpha-terpineol, cyclopentanecarboxamide, guaiol (a sesquiterpenoid alcohol), 1H-cyclopropanaphthalene, tetracyclotridecan-9-ol, dormin/abscisic acid, and epiglobulol, with the respective protein molecules, evidenced the cardioprotective effect of P. guajava leaves. Hence, it was concluded that the ethanolic leaves extract of P. guajava leaves have a cardioprotective effect.
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