金属喹诺酮[Cd2(nal)2(phen)2(Cl)2]的合成、表征及抗真菌研究

A. Debnath, F. Hussain, D. Masram
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引用次数: 6

摘要

在含n杂环配体1,10-菲罗啉(Phen)存在下,合成了一种新的双核畸变八面体钠二酸(nal)与镉(II)金属离子配合物[Cd2(nal) 2(Phen)2(Cl)2]。利用CHN分析、傅里叶变换红外、热重分析、差示扫描比色、核磁共振、紫外可见和单晶x射线衍射对合成的金属配合物进行了表征。与母体喹诺酮相比,新合成的配合物对蛇皮霉、罗氏菌核菌、solani根丝核菌和bataticola根丝核菌的抑菌活性更明显。
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Synthesis, characterization and antifungal studies of metalloquinolone [Cd2(nal)2(phen)2(Cl)2]
A novel dinuclear, distorted octahedral complex of nalidixic acid (nal) with Cd(II) metal ion with the formula [Cd2(Nal)2(Phen)2(Cl)2] has been synthesized in the presence of N-containing heterocyclic ligand, 1,10-phenanthroline (phen). The synthesized metal complex was characterized using CHN analysis, Fourier transformed infra-red, thermo gravimetric analysis, differential scanning chalorimetry, nuclear magnetic resonance, ultra violet-visible and single-crystal X-ray diffraction. The newly synthesized complex shows more pronounced antifungal activity compared with the parent quinolone against four fungi, namely Pythium aphanidermatum, Sclerotinia rolfsii, Rhizoctonia solani and Rhizoctonia bataticola.
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