{"title":"基于机器学习的蛋白质特征预测b细胞表位区域","authors":"Fatema Nafa, Ryan Kanoff","doi":"10.5121/csit.2022.121811","DOIUrl":null,"url":null,"abstract":"Considering the current state of Covid-19 pandemic, vaccine research and production is more important than ever. Antibodies recognize epitopes, which are immunogenic regions of antigen, in a very specific manner, to trigger an immune response. It is extremely difficult to predict such locations, yet they have substantial implications for complex humoral immunogenicity pathways. This paper presents a machine learning epitope prediction model. The research creates several models to test the accuracy of B-cell epitope prediction based solely on protein features. The goal is to establish a quantitative comparison of the accuracy of three machine learning models, XGBoost, CatBoost, and LightGbM. Our results found similar accuracy between the XGBoost and LightGbM models with the CatBoost model having the highest accuracy of 82%. Though this accuracy is not high enough to be considered reliable it does warrant further research on the subject.","PeriodicalId":91205,"journal":{"name":"Artificial intelligence and applications (Commerce, Calif.)","volume":"117 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Machine Learning based to Predict B-Cell Epitope Region Utilizing Protein Features\",\"authors\":\"Fatema Nafa, Ryan Kanoff\",\"doi\":\"10.5121/csit.2022.121811\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Considering the current state of Covid-19 pandemic, vaccine research and production is more important than ever. Antibodies recognize epitopes, which are immunogenic regions of antigen, in a very specific manner, to trigger an immune response. It is extremely difficult to predict such locations, yet they have substantial implications for complex humoral immunogenicity pathways. This paper presents a machine learning epitope prediction model. The research creates several models to test the accuracy of B-cell epitope prediction based solely on protein features. The goal is to establish a quantitative comparison of the accuracy of three machine learning models, XGBoost, CatBoost, and LightGbM. Our results found similar accuracy between the XGBoost and LightGbM models with the CatBoost model having the highest accuracy of 82%. Though this accuracy is not high enough to be considered reliable it does warrant further research on the subject.\",\"PeriodicalId\":91205,\"journal\":{\"name\":\"Artificial intelligence and applications (Commerce, Calif.)\",\"volume\":\"117 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-10-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Artificial intelligence and applications (Commerce, Calif.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5121/csit.2022.121811\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Artificial intelligence and applications (Commerce, Calif.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5121/csit.2022.121811","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Machine Learning based to Predict B-Cell Epitope Region Utilizing Protein Features
Considering the current state of Covid-19 pandemic, vaccine research and production is more important than ever. Antibodies recognize epitopes, which are immunogenic regions of antigen, in a very specific manner, to trigger an immune response. It is extremely difficult to predict such locations, yet they have substantial implications for complex humoral immunogenicity pathways. This paper presents a machine learning epitope prediction model. The research creates several models to test the accuracy of B-cell epitope prediction based solely on protein features. The goal is to establish a quantitative comparison of the accuracy of three machine learning models, XGBoost, CatBoost, and LightGbM. Our results found similar accuracy between the XGBoost and LightGbM models with the CatBoost model having the highest accuracy of 82%. Though this accuracy is not high enough to be considered reliable it does warrant further research on the subject.