DETECTION AND ITS CLINICAL SIGNIFICANCE OF FIBRINOGEN-BOUND SIALIC LEVELS IN PATIENTS WITH LIVER DISEASE

Objective:To explore the clinical significance of fibrinogen-bound sialic acid levels in patients with liver disease.Methods:Fibrinogen was purified by precipitation from citrated plasma by saturated ammonium sulplvate.Fibrinogen-bound sialic acid levels with 22 controls and 113 liver patients were assayed by the thiobarbituric acid method.Results:The level of the patients with liver cirrhosis was significantly higher than that of the controls and others liver disease group (P0.01).In addition there was relationship between the thrombin time and fibrinogen-bound sialic acid contents.Poly merization of fibrin monomer was inverse ratio with fibrinogen-bound sialic acid.Conclusion:It suggests that fibrinogen-bound sialic acid levels may be diagnostic index acquired dysfibrinogenaemia.